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Qianqian ZHENG


Liangwei DUAN




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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.1 P.19-41


A dynamically evolving war between autophagy and pathogenic microorganisms

Author(s):  Qianqian ZHENG, Liangwei DUAN, Yang ZHANG, Jiaoyang LI, Shiyu ZHANG, Hui WANG

Affiliation(s):  Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China; more

Corresponding email(s):   wanghui@xxmu.edu.cn

Key Words:  Autophagy, Pathogenic microorganism, Bacteria, Virus, Fungi, Parasite

Qianqian ZHENG, Liangwei DUAN, Yang ZHANG, Jiaoyang LI, Shiyu ZHANG, Hui WANG. A dynamically evolving war between autophagy and pathogenic microorganisms[J]. Journal of Zhejiang University Science B, 2022, 23(1): 19-41.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T A dynamically evolving war between autophagy and pathogenic microorganisms
%A Qianqian ZHENG
%A Liangwei DUAN
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%A Shiyu ZHANG
%J Journal of Zhejiang University SCIENCE B
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%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100285

T1 - A dynamically evolving war between autophagy and pathogenic microorganisms
A1 - Qianqian ZHENG
A1 - Liangwei DUAN
A1 - Yang ZHANG
A1 - Jiaoyang LI
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A1 - Hui WANG
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100285

autophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting organisms from environmental stress. autophagy can help the host to eliminate invading pathogens, including bacteria, viruses, fungi, and parasites. However, pathogens have evolved multiple strategies to interfere with autophagic signaling pathways or inhibit the fusion of autophagosomes with lysosomes to form autolysosomes. Moreover, host cell matrix degradation by different types of autophagy can be used for the proliferation and reproduction of pathogens. Thus, determining the roles and mechanisms of autophagy during pathogen infections will promote understanding of the mechanisms of pathogen‍‒‍host interactions and provide new strategies for the treatment of infectious diseases.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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