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 ORCID:

Wenchuan WU

https://orcid.org/0000-0001-6317-3417

Ning PU

https://orcid.org/0000-0002-3123-493X

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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.12 P.971-984

http://doi.org/10.1631/jzus.B2100110


Basophils as a potential therapeutic target in cancer


Author(s):  Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU

Affiliation(s):  Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; more

Corresponding email(s):   npu15@fudan.edu.cn, wu.wenchuan@zs-hospital.sh.cn

Key Words:  Basophil, Cancer, Cytokine, Chemokine, Tumor microenvironment


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Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU. Basophils as a potential therapeutic target in cancer[J]. Journal of Zhejiang University Science B, 2021, 22(12): 971-984.

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author="Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU",
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volume="22",
number="12",
pages="971-984",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100110"
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%A Wenchuan WU
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A1 - Jicheng ZHANG
A1 - Hanlin YIN
A1 - Qiangda CHEN
A1 - Guochao ZHAO
A1 - Wenhui LOU
A1 - Wenchuan WU
A1 - Ning PU
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VL - 22
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SP - 971
EP - 984
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100110


Abstract: 
basophils, which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation, have been neglected by researchers in the past decades. Previous studies have revealed their vital roles in allergic diseases and parasitic infections. Intriguingly, recent studies even reported that basophils might be associated with cancer development, as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers. However, it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components; the answer may depend on the tumor biology and the microenvironment. Herein, we reviewed the role of basophils in cancers, and highlighted some potential and promising therapeutic strategies.

嗜碱性粒细胞作为治疗癌症的潜在靶点

概要:嗜碱性粒细胞是外周血中比例最少的粒细胞,曾一度被认为是肥大细胞的"冗余亲属",在过去的几十年里一直被研究人员忽视。以往的研究揭示了其在过敏性疾病和寄生虫感染中的重要作用,最新研究则表明嗜碱性粒细胞可能与肿瘤的发生发展同样具有密切关联。活化的嗜碱性粒细胞合成并释放多种细胞因子和趋化因子参与并调控肿瘤的发生发展。然而,嗜碱性粒细胞究竟扮演着抑癌还是促癌的角色至今仍存在较大争议,这可能取决于肿瘤生物学行为以及微环境的影响。因此,我们回顾了嗜碱性粒细胞的生物学功能及其在肿瘤发生发展中的潜在作用,并展望其在肿瘤治疗中的应用前景。

关键词:嗜碱性粒细胞;癌症;细胞因子;趋化因子;肿瘤微环境

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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