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 ORCID:

Ling Xia

https://orcid.org/0000-0002-1937-9693

Dingchang ZHENG

https://orcid.org/0000-0001-8077-4548

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.123-140

http://doi.org/10.1631/jzus.B2100425


Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease


Author(s):  Yingyi GENG, Xintong WU, Haipeng LIU, Dingchang ZHENG, Ling XIA

Affiliation(s):  Key Laboratory for Biomedical Engineering of Ministry of Education, Institute of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   xialing@zju.edu.cn, dingchang.zheng@coventry.ac.uk

Key Words:  Index of microcirculatory resistance (IMR), Coronary artery disease (CAD), Computational simulation


Yingyi GENG, Xintong WU, Haipeng LIU, Dingchang ZHENG, Ling XIA. Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease[J]. Journal of Zhejiang University Science B, 2022, 23(2): 123-140.

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author="Yingyi GENG, Xintong WU, Haipeng LIU, Dingchang ZHENG, Ling XIA",
journal="Journal of Zhejiang University Science B",
volume="23",
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year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100425"
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%T Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease
%A Yingyi GENG
%A Xintong WU
%A Haipeng LIU
%A Dingchang ZHENG
%A Ling XIA
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100425

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T1 - Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease
A1 - Yingyi GENG
A1 - Xintong WU
A1 - Haipeng LIU
A1 - Dingchang ZHENG
A1 - Ling XIA
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 2
SP - 123
EP - 140
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100425


Abstract: 
The dysfunction of coronary microcirculation is an important cause of coronary artery disease (CAD). The index of microcirculatory resistance (IMR) is a quantitative evaluation of coronary microcirculatory function, which provides a significant reference for the prediction, diagnosis, treatment, and prognosis of CAD. IMR also plays a key role in investigating the interaction between epicardial and microcirculatory dysfunctions, and is closely associated with coronary hemodynamic parameters such as flow rate, distal coronary pressure, and aortic pressure, which have been widely applied in computational studies of CAD. However, there is currently a lack of consensus across studies on the normal and pathological ranges of IMR. The relationships between IMR and coronary hemodynamic parameters have not been accurately quantified, which limits the application of IMR in computational CAD studies. In this paper, we discuss the research gaps between IMR and its potential applications in the computational simulation of CAD. computational simulation based on the combination of IMR and other hemodynamic parameters is a promising technology to improve the diagnosis and guide clinical trials of CAD.

微循环阻力指数(IMR):冠状动脉疾病计算仿真的最新和潜在应用

概要:冠状动脉微循环功能异常是冠状动脉疾病(CAD)发生的重要原因。微循环阻力指数(IMR)是定量评价冠状动脉微循环功能的指标,为冠状动脉疾病的早期预测、诊断、治疗及预后提供了重要参考。IMR在研究心外膜和微循环功能障碍之间的相互作用方面起着关键作用,并与一些血流动力学参数(例如流速、远端冠脉压力和主动脉压力)密切相关,这些参数已广泛应用于CAD的计算研究。然而,目前IMR的正常范围与病理范围缺乏一致性。IMR与其他血流动力学参数之间的关系尚未被准确量化,这限制了IMR在CAD计算研究中的应用。在这篇文章中,我们讨论了IMR与CAD计算仿真方面的研究空白和应用潜力。在未来,将IMR与其他血流动力学结合应用在计算模拟中,有望提高CAD诊断水平以及为相关临床实验提供重要参考。

关键词:微循环阻力指数(IMR);冠状动脉疾病(CAD);计算仿真

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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