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 ORCID:

Yuting LU

https://orcid.org/0000-0003-2840-3517

Huayi LIU

https://orcid.org/0000-0002-7571-7335

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.1 P.1-18

http://doi.org/10.1631/jzus.B2100182


A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine


Author(s):  Yuting LU, Huayi LIU, Kuo YANG, Yijia MAO, Lingkai MENG, Liu YANG, Guangze OUYANG, Wenjie LIU

Affiliation(s):  Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301608, China; more

Corresponding email(s):   15900369830@163.com

Key Words:  Gastric cancer (GC), Gastric premalignant condition (GPC), Precancerous lesion of gastric cancer (PLGC), Gastrointestinal microflora, Intervention by traditional Chinese medicine (TCM)


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Yuting LU, Huayi LIU, Kuo YANG, Yijia MAO, Lingkai MENG, Liu YANG, Guangze OUYANG, Wenjie LIU. A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine[J]. Journal of Zhejiang University Science B, 2022, 23(1): 1-18.

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volume="23",
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pages="1-18",
year="2022",
publisher="Zhejiang University Press & Springer",
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%A Yuting LU
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%A Liu YANG
%A Guangze OUYANG
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A1 - Yuting LU
A1 - Huayi LIU
A1 - Kuo YANG
A1 - Yijia MAO
A1 - Lingkai MENG
A1 - Liu YANG
A1 - Guangze OUYANG
A1 - Wenjie LIU
J0 - Journal of Zhejiang University Science B
VL - 23
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SP - 1
EP - 18
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100182


Abstract: 
With the recent upsurge of studies in the field of microbiology, we have learned more about the complexity of the gastrointestinal microecosystem. More than 30 genera and 1000 species of gastrointestinal microflora have been found. The structure of the normal microflora is relatively stable, and is in an interdependent and restricted dynamic equilibrium with the body. In recent years, studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer (GC) and precancerous lesions. So, restoring the balance of gastrointestinal microflora is of great significance. Moreover, intervention in gastric premalignant condition (GPC), also known as precancerous lesion of gastric cancer (PLGC), has been the focus of current clinical studies. The holistic view of traditional Chinese medicine (TCM) is consistent with the microecology concept, and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract, restoring the homeostasis of gastrointestinal microflora to prevent canceration. However, large gaps in knowledge remain to be addressed. This review aims to provide new ideas and a reference for clinical practice.

胃肠菌群、胃癌及癌前病变与中药防治的最新研究进展

概要:随微生物领域研究热潮的出现,人们了解到胃肠微生态是一个复杂的系统,目前已知的胃肠菌群大概有30个属共1000多种。正常的菌群结构相对稳定,与人体处于一种相互依存及制约的动态平衡状态。近年来研究表明,胃肠菌群失调与胃癌及癌前病变存在潜在联系,有效地修复胃肠菌群的平衡对于防治癌变有着显著意义。对癌前状态的干预治疗一直是临床研究的热点。中医整体观与微生态学统一观在理念上相合,且中药通过口服进入消化道以后,可以直接和胃肠道的菌群起双向调节作用,帮助修复胃肠菌群稳态以防治癌变。基于目前的研究,仍存在较大的空白领域等待探索,鉴此本文进行综述以向临床提供新的思路和借鉴。

关键词:胃癌;胃癌前病变;胃肠菌群;中药防治

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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