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On-line Access: 2022-06-08

Received: 2021-12-28

Revision Accepted: 2022-02-14

Crosschecked: 2022-06-08

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jingru GUO

https://orcid.org/0000-0001-9333-2773

Huanmin YANG

https://orcid.org/0000-0003-3323-6522

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.6 P.461-480

http://doi.org/10.1631/jzus.B2101091


Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress


Author(s):  Jingjing LU, Shoupeng FU, Jie DAI, Jianwen HU, Shize LI, Hong JI, Zhiquan WANG, Jiahong YU, Jiming BAO, Bin XU, Jingru GUO, Huanmin YANG

Affiliation(s):  College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China; more

Corresponding email(s):   guojingru@byau.edu.cn, yanghm@byau.edu.cn

Key Words:  Low temperature, Stress, Autophagy, Metabolic reprogramming, Histone


Jingjing LU, Shoupeng FU, Jie DAI, Jianwen HU, Shize LI, Hong JI, Zhiquan WANG, Jiahong YU, Jiming BAO, Bin XU, Jingru GUO, Huanmin YANG. Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress[J]. Journal of Zhejiang University Science B, 2022, 23(6): 461-480.

@article{title="Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress",
author="Jingjing LU, Shoupeng FU, Jie DAI, Jianwen HU, Shize LI, Hong JI, Zhiquan WANG, Jiahong YU, Jiming BAO, Bin XU, Jingru GUO, Huanmin YANG",
journal="Journal of Zhejiang University Science B",
volume="23",
number="6",
pages="461-480",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2101091"
}

%0 Journal Article
%T Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress
%A Jingjing LU
%A Shoupeng FU
%A Jie DAI
%A Jianwen HU
%A Shize LI
%A Hong JI
%A Zhiquan WANG
%A Jiahong YU
%A Jiming BAO
%A Bin XU
%A Jingru GUO
%A Huanmin YANG
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 6
%P 461-480
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2101091

TY - JOUR
T1 - Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress
A1 - Jingjing LU
A1 - Shoupeng FU
A1 - Jie DAI
A1 - Jianwen HU
A1 - Shize LI
A1 - Hong JI
A1 - Zhiquan WANG
A1 - Jiahong YU
A1 - Jiming BAO
A1 - Bin XU
A1 - Jingru GUO
A1 - Huanmin YANG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 6
SP - 461
EP - 480
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2101091


Abstract: 
The negative effects of low temperature can readily induce a variety of diseases. We sought to understand the reasons why cold stress induces disease by studying the mechanisms of fine-tuning in macrophages following cold exposure. We found that cold stress triggers increased macrophage activation accompanied by metabolic reprogramming of aerobic glycolysis. The discovery, by genome-wide RNA sequencing, of defective mitochondria in mice macrophages following cold exposure indicated that mitochondrial defects may contribute to this process. In addition, changes in metabolism drive the differentiation of macrophages by affecting histone modifications. Finally, we showed that histone acetylation and lactylation are modulators of macrophage differentiation following cold exposure. Collectively, metabolism-related epigenetic modifications are essential for the differentiation of macrophages in cold-stressed mice, and the regulation of metabolism may be crucial for alleviating the harm induced by cold stress.

冷应激下小鼠巨噬细胞的代谢和表观遗传修饰反应

逯静静1,付守鹏2,戴捷3,呼建文3,李士泽1,计红1,王志全4,于佳红1,暴济铭1,徐彬1,郭景茹1,杨焕民1
1黑龙江八一农垦大学动物科技学院,中国大庆市,163319
2吉林大学动物医学学院,中国长春市,130062
3上海拜谱生物科技有限公司,中国上海市,201100
4阿尔伯塔大学农业、生命与环境科学学院,加拿大埃德蒙顿,Alberta T5J 4P6
摘要:低温对健康的负面影响容易诱发多种疾病,因此我们试图通过研究冷暴露后巨噬细胞微调的机制来了解冷应激诱发疾病的原因。在本研究中,我们发现冷应激会引发巨噬细胞活化增加,并伴随有氧糖酵解的代谢重编程,而且冷暴露后的线粒体缺陷可能有助于这一过程。全基因组RNA测序的结果进一步确定了冷暴露后小鼠巨噬细胞中的线粒体缺陷。此外,新陈代谢的变化通过影响组蛋白修饰来驱动巨噬细胞的分化。最后,我们发现组蛋白乙酰化和乳酸化是冷暴露后巨噬细胞分化的调节剂。总而言之,代谢相关的表观遗传修饰对于冷应激小鼠巨噬细胞的分化至关重要,而代谢调控可能有助于减轻冷应激的危害。

关键词:低温;应激;自噬;代谢重编程;组蛋白

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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