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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300607


The role of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment


Author(s):  Shihua ZHANG, Jianmin GUO, Yuting HE, Zhiang SU, Yao FENG, Lan ZHANG, Jun ZOU, Xiquang WENG, Yu YUAN

Affiliation(s):  School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China; more

Corresponding email(s):   yuanyumail@126.com, wengxq@gzsport.edu.cn

Key Words:  lncRNAs, Osteogenesis, Bone angiogenesis, Osteoporosis, Bone microenvironment


Shihua ZHANG, Jianmin GUO, Yuting HE, Zhiang SU, Yao FENG, Lan ZHANG, Jun ZOU, Xiquang WENG, Yu YUAN. The role of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300607"
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A1 - Yao FENG
A1 - Lan ZHANG
A1 - Jun ZOU
A1 - Xiquang WENG
A1 - Yu YUAN
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Abstract: 
Bone is a highly calcified and vascularized tissue. The vascular system plays a vital role in supporting bone growth and repair, such as the provision of nutrients, growth factors, and metabolic waste transfer. Moreover, the additional functions of the bone vasculature, such as the secretion of various factors and the regulation of bone-related signaling pathways, are essential for maintaining bone health. In the bone microenvironment, bone tissue cells play a critical role in regulating angiogenesis, including osteoblasts, bone marrow mesenchymal stem cells (BMSCs), osteoclasts, and others. osteogenesis and bone angiogenesis are closely linked. The decrease in osteogenesis and bone angiogenesis caused by aging leads to osteoporosis. Long noncoding RNAs (lncRNAs) are involved in various physiological processes, including osteogenesis and angiogenesis. Recent studies have shown that lncRNAs could mediate the crosstalk between angiogenesis and osteogenesis. However, the mechanism by which lncRNAs regulate angiogenesis–osteogenesis crosstalk remains unclear. In this review, we describe in detail the ways in which lncRNAs regulate the crosstalk between osteogenesis and angiogenesis to promote bone health, aiming to provide new directions for the study of the mechanism by which lncRNAs regulate bone metabolism.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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