CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2023-05-16
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Xuetao ZHAO, Hongbing LIN, Tong DING, Yawei WANG, Na LIU, Yuqin SHEN. Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment[J]. Journal of Zhejiang University Science B, 2023, 24(5): 373-386.
@article{title="Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment",
author="Xuetao ZHAO, Hongbing LIN, Tong DING, Yawei WANG, Na LIU, Yuqin SHEN",
journal="Journal of Zhejiang University Science B",
volume="24",
number="5",
pages="373-386",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200576"
}
%0 Journal Article
%T Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment
%A Xuetao ZHAO
%A Hongbing LIN
%A Tong DING
%A Yawei WANG
%A Na LIU
%A Yuqin SHEN
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 5
%P 373-386
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200576
TY - JOUR
T1 - Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment
A1 - Xuetao ZHAO
A1 - Hongbing LIN
A1 - Tong DING
A1 - Yawei WANG
A1 - Na LIU
A1 - Yuqin SHEN
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 5
SP - 373
EP - 386
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200576
Abstract: periodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell behavior changes in response to changes in the microenvironment, which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells. It has been confirmed that periodontal ligament stem cells (PDLSCs) are vital in the development of periodontal disease. Moreover, PDLSCs are the most effective cell type to be used for periodontium regeneration. This review focuses on changes in PDLSCs, their basic biological behavior, osteogenic differentiation, and drug effects caused by the inflammatory microenvironment, to provide a better understanding of the influence of these factors on periodontal tissue homeostasis. In addition, we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment.
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