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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.10 P.868-882


Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside

Author(s):  Xinjia CAI, Jianyun ZHANG, Heyu ZHANG, Tiejun LI

Affiliation(s):  Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China; more

Corresponding email(s):   litiejun22@vip.sina.com, zhangheyu1983@sina.cn

Key Words:  Oral leukoplakia, Oral squamous cell carcinoma, Malignant transformation, Biomarker, Prognosis

Xinjia CAI, Jianyun ZHANG, Heyu ZHANG, Tiejun LI. Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside[J]. Journal of Zhejiang University Science B, 2023, 24(10): 868-882.

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author="Xinjia CAI, Jianyun ZHANG, Heyu ZHANG, Tiejun LI",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200589

T1 - Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside
A1 - Xinjia CAI
A1 - Jianyun ZHANG
A1 - Heyu ZHANG
A1 - Tiejun LI
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 10
SP - 868
EP - 882
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200589

oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.


蔡鑫嘉1,3, 张建运1,3, 张荷钰2,3, 李铁军1,3
1北京大学口腔医学院病理科 / 国家口腔医学中心 / 国家口腔疾病临床医学研究中心 / 口腔生物材料和数字诊疗装备国家工程研究中心,中国北京市,100081


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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