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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.10 P.868-882

http://doi.org/10.1631/jzus.B2200589


Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside


Author(s):  Xinjia CAI, Jianyun ZHANG, Heyu ZHANG, Tiejun LI

Affiliation(s):  Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China; more

Corresponding email(s):   litiejun22@vip.sina.com, zhangheyu1983@sina.cn

Key Words:  Oral leukoplakia, Oral squamous cell carcinoma, Malignant transformation, Biomarker, Prognosis


Xinjia CAI, Jianyun ZHANG, Heyu ZHANG, Tiejun LI. Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside[J]. Journal of Zhejiang University Science B, 2023, 24(10): 868-882.

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pages="868-882",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200589"
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A1 - Jianyun ZHANG
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2200589


Abstract: 
oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.

口腔白斑癌变生物标志物:从基础科研到临床应用

蔡鑫嘉1,3, 张建运1,3, 张荷钰2,3, 李铁军1,3
1北京大学口腔医学院病理科 / 国家口腔医学中心 / 国家口腔疾病临床医学研究中心 / 口腔生物材料和数字诊疗装备国家工程研究中心,中国北京市,100081
2北京大学口腔医学院中心实验室,中国北京市,100081
3中国医学科学院口腔颌面部肿瘤精准病理诊断创新单元(2019RU034),中国北京市,100081
摘要:口腔白斑是一种常见的口腔潜在恶性病变,可恶变为口腔鳞状细胞癌,恶性潜能较高。白斑癌变严重影响患者的生存和生活质量,但因缺乏有效的癌变预测生物标志物,难以对其癌变潜能进行识别。作为头颈病理领域的重要问题之一,白斑癌变生物标志物的筛选将有助于鳞癌的早期诊断。本文通过综述白斑癌变相关生物标志物的相关研究,探讨从基础科研到临床转化的前景。目前虽尚无生物标志物应用于临床,但基因组不稳定性可能是一种具有应用前景的辅助方法。

关键词:口腔白斑;口腔鳞状细胞癌;癌变;生物标志物;预后

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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