Full Text:
<321>
Summary: 
<87>
CLC number:
On-line Access: 2023-06-13
Received: 2023-01-18
Revision Accepted: 2023-03-03
Crosschecked: 2023-07-21
Cited: 0
Clicked: 398
Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection
| ||||||||||||||
Zhaodi WANG, Xuan LU, Yunmei YANG, Yuanqiang LU. Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection[J]. Journal of Zhejiang University Science B, 2023, 24(6): 539-542.
@article{title="Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection",
author="Zhaodi WANG, Xuan LU, Yunmei YANG, Yuanqiang LU",
journal="Journal of Zhejiang University Science B",
volume="24",
number="6",
pages="539-542",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300024"
}
%0 Journal Article
%T Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection
%A Zhaodi WANG
%A Xuan LU
%A Yunmei YANG
%A Yuanqiang LU
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 6
%P 539-542
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300024
TY - JOUR
T1 - Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection
A1 - Zhaodi WANG
A1 - Xuan LU
A1 - Yunmei YANG
A1 - Yuanqiang LU
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 6
SP - 539
EP - 542
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300024
Abstract: epstein-Barr virus (EBV), a double-stranded DNA virus with an envelope, is a ubiquitous pathogen that is prevalent in humans, although most people who contract it do not develop symptoms (Kerr, 2019). While the primary cells EBV attacks are epithelial cells and B lymphocytes, its target range expands to a variety of cell types in immunodeficient hosts. Serological change occurs in 90% of infected patients. Therefore, immunoglobulin M (IgM) and IgG, serologically reactive to viral capsid antigens, are reliable biomarkers for the detection of acute and chronic EBV infections (Cohen, 2000). Symptoms of EBV infection vary according to age and immune status. Young patients with primary infection may present with infectious mononucleosis; there is a typical triad of symptoms including fever, angina, and lymphadenectasis (Houen and Trier, 2021). In immunocompromised patients, response after EBV infection may be atypical, with unexplained fever. The nucleic acid of EBV can be detected to confirm whether high-risk patients are infected (Smets et al., 2000). EBV is also associated with the occurrence of certain tumors (such as lymphoma and nasopharyngeal carcinoma) because it transforms host cells (Shannon-Lowe et al., 2017; Tsao et al., 2017).
[1]ChungHJ, ChiHS, JangS, et al., 2010. Epstein-Barr virus infection associated with bone marrow fibrin-ring granuloma. Am J Clin Pathol, 133(2):300-304.
[2]CohenJI, 2000. Epstein-Barr virus infection. N Engl J Med, 343(7):481-492.
[3]FialaM, ColodroI, TalbertW, et al., 1987. Bone marrow granulomas in mononucleosis. Postgrad Med J, 63(738):277-279.
[4]FiorentinoDF, ZlotnikA, VieiraP, et al., 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by TH1 cells. J Immunol, 146(10):3444-3451.
[5]GlaserR, LitskyML, PadgettDA, et al., 2006. EBV-encoded dUTPase induces immune dysregulation: implications for the pathophysiology of EBV-associated disease. Virology, 346(1):205-218.
[6]HouenG, TrierNH, 2021. Epstein-Barr virus and systemic autoimmune diseases. Front Immunol, 11:587380.
[7]JiangS, ZhangWY, LuYQ, 2022. Development and valid
[8]ation of novel inflammatory response-related gene signature for sepsis prognosis. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 23(12):1028-1041.
[9]KerrJR, 2019. Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors. J Clin Pathol, 72(10):651-658.
[10]LuX, YangYM, LuYQ, 2022. Immunosenescence: a critical factor associated with organ injury after sepsis. Front Immunol, 13:917293.
[11]MakinoK, TakeichiO, HatoriK, et al., 2015. Epstein-Barr virus infection in chronically inflamed periapical granulomas. PLoS ONE, 10(4):e0121548.
[12]MelaniC, JaffeES, WilsonWH, 2020. Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder. Blood, 135(16):1344-1352.
[13]NakaiH, KawamuraY, SugataK, et al., 2012. Host factors associated with the kinetics of Epstein-Barr virus DNA load in patients with primary Epstein-Barr virus infection. Microbiol Immunol, 56(2):93-98.
[14]NowalkA, GreenM, 2016. Epstein-Barr virus. Microbiol Spectr, 4(3):4.3.47.
[15]Shannon-LoweC, RickinsonAB, BellAI, 2017. Epstein-Barr virus-associated lymphomas. Phil Trans Roy Soc B Biol Sci, 372(1732):20160271.
[16]SinSH, DittmerDP, 2012. Cytokine homologs of human gammaherpesviruses. J Interferon Cytokine Res, 32(2):53-59.
[17]SmetsF, BodeusM, GoubauP, et al., 2000. Characteristics of Epstein-Barr virus primary infection in pediatric liver transplant recipients. J Hepatol, 32(1):100-104.
[18]TsaoSW, TsangCM, LoKW, 2017. Epstein-Barr virus infection and nasopharyngeal carcinoma. Phil Trans Roy Soc B Biol Sci, 372(1732):20160270.
[19]VolaricAK, SinghK, GruAA, 2021. Rare EBV-associated B cell neoplasms of the gastrointestinal tract. Semin Diagn Pathol, 38(4):38-45.
[20]ZhangW, KazeemBB, YangHT, et al., 2021. Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(9):782-790.
ORCID: 
Open peer comments: Debate/Discuss/Question/Opinion
<1>