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Abstract: pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory infections, sepsis, osteomyelitis, endocarditis, and urinary tract infections in burned or immunocompromised patients (Azam and Khan, 2019; Chai and Xu, 2020; Voth et al., 2020). P. aeruginosa is a naturally drug-resistant bacterium that is resistant to a wide range of antibiotics, making it one of the major opportunistic pathogens leading to in-hospital infections (Pang et al., 2019; Chai and Xu, 2020; Reynolds and Kollef, 2021). According to the surveillance report of the China Antimicrobial Resistance Surveillance System (CARSS, http://www.carss.cn), Gram-negative bacteria accounted for more than 70% of all bacterial infections, and P. aeruginosa accounted for 12.4%, 12.0%, and 12.2% in 2018, 2019, and 2020, respectively. Therefore, P. aeruginosa infection has become an important concern in public health care, and it is particularly important to gain insight into the means of host immune defense against P. aeruginosa infection.

铜绿假单胞菌诱导的线粒体功能障碍以ROS依赖性的方式抑制促炎细胞因子分泌并增强小鼠巨噬细胞的细胞毒性

[1]AishwaryaR,AlamS,AbdullahCS,et al.,2020.Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes.Redox Biol,36:101660.

[2]AndrieuxP,ChevillardC,Cunha-NetoE,et al.,2021.Mitochondria as a cellular hub in infection and inflammation.Int J Mol Sci,22(21):11338.

[3]AzamMW,KhanAU,2019.Updates on the pathogenicity status ofPseudomonasaeruginosa.Drug Discov Today,24(1):350-359.

[4]BanothB,CasselSL,2018.Mitochondria in innate immune signaling.Transl Res,202:52-68.

[5]ChaiYH,XuJF,2020.How doesPseudomonas aeruginosa affect the progression of bronchiectasis?Clin Microbiol Infect,26(3):313-318.

[6]ChenC,ZhouQJ,LiZY,et al.,2022.Hyperglycemia induces corneal endothelial dysfunction through attenuating mitophagy.Exp Eye Res,215:108903.

[7]DengQC,WangY,ZhangYQ,et al.,2015.Pseudomonasaeruginosa triggers macrophage autophagy to escape intracellular killing by activation of the NLRP3 inflammasome.Infect Immun,84(1):56-66.

[8]DeoP,ChowSH,HanML,et al.,2020.Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation.Nat Microbiol,5(11):1418-1427.

[9]GluschkoA,FaridA,HerbM,et al.,2022.Macrophages targetListeria monocytogenes by two discrete non-canonical autophagy pathways.Autophagy,18(5):‍1090-1107.

[10]JangraV,SharmaN,ChhillarAK,2022.Therapeutic approaches for combatingPseudomonasaeruginosa infections.Microbes Infect,24(4):104950.

[11]JariyamanaN,ChuveeraP,DewiA,et al.,2021.Effects of N-acetyl cysteine on mitochondrial ROS, mitochondrial dynamics, and inflammation on lipopolysaccharide-treated human apical papilla cells.Clin Oral Investig,25(6):3919-3928.

[12]Jurado-MartínI,Sainz-MejíasM,McCleanS,2021.Pseudomonasaeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors.Int J Mol Sci,22(6):3128.

[13]KrakauerT,2019.Inflammasomes, autophagy, and cell death: the trinity of innate host defense against intracellular bacteria.Mediators Inflamm,2019:2471215.

[14]LinQS,LiS,JiangN,et al.,2019.PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.Redox Biol,26:101254.

[15]OrnatowskiW,LuQ,YegambaramM,et al.,2020.Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.Redox Biol,36:101679.

[16]PalikarasK,LionakiE,TavernarakisN,2018.Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.Nat Cell Biol,20(9):1013-1022.

[17]PangZ,RaudonisR,GlickBR,et al.,2019.Antibiotic resistance inPseudomonasaeruginosa: mechanisms and alternative therapeutic strategies.Biotechnol Adv,37(1):177-192.

[18]PatoliD,MignotteF,DeckertV,et al.,2020.Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis.J Clin Invest,130(11):5858-5874.

[19]PicklesS,VigiéP,YouleRJ,2018.Mitophagy and quality control mechanisms in mitochondrial maintenance.Curr Biol,28(4):R170-R185.

[20]RaghuG,BerkM,CampochiaroPA,et al.,2021.The multifaceted therapeutic role ofN-acetylcysteine (NAC) in disorders characterized by oxidative stress.Curr Neuropharmacol,19(8):1202-1224.

[21]RamondE,JametA,CoureuilM,et al.,2019.Pivotal role of mitochondria in macrophage response to bacterial pathogens.Front Immunol,10:2461.

[22]ReynoldsD,KollefM,2021.The epidemiology and pathogenesis and treatment ofPseudomonasaeruginosa infections: an update.Drugs,81(18):2117-2131.

[23]RoxasJL,RamamurthyS,CocchiK,et al.,2022.EnteropathogenicEscherichia coli regulates host-cell mitochondrial morphology.Gut Microbes,14(1):2143224.

[24]SilwalP,KimJK,KimYJ,et al.,2020.Mitochondrial reactive oxygen species: double-edged weapon in host defense and pathological inflammation during infection.Front Immunol,11:1649.

[25]StefanoGB,PtacekR,PtackovaH,et al.,2021.Selective neuronal mitochondrial targeting in SARS-CoV-2 infection affects cognitive processes to induce ‘brain fog’ and results in behavioral changes that favor viral survival.Med Sci Monit,27:e930886.

[26]SuLJ,ZhangJH,GomezH,et al.,2023.Mitochondria ROS and mitophagy in acute kidney injury.Autophagy,19(2):401-414.

[27]SunLL,ShaoYN,YouMX,et al.,2022.ROS-mediated BNIP3-dependent mitophagy promotes coelomocyte survival inApostichopus japonicus in response toVibrio splendidus infection.Zool Res,43(2):285-300.

[28]TsaiML,TsaiYG,LinYC,et al.,2022.IL-25 induced ROS-mediated M2 macrophage polarization via AMPK-associated mitophagy.Int J Mol Sci,23(1):3.

[29]VothS,GwinM,FrancisCM,et al.,2020.VirulentPseudomonasaeruginosa infection converts antimicrobial amyloids into cytotoxic prions.FASEB J,34(7):9156-9179.

[30]WangKR,MaHW,LiuH,et al.,2019.The glycoprotein and nucleocapsid protein of hantaviruses manipulate autophagy flux to restrain host innate immune responses.Cell Rep,27(7):2075-2091.e5.

[31]YooSM,JungYK,2018.A molecular approach to mitophagy and mitochondrial dynamics.Mol Cells,41(1):18-26.

[32]ZhangW,KazeemBB,YangH,et al.,2021.Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-‍κB pathways.J Zhejiang Univ-Sci B (Biomed & Biotechnol),22(9):782-790.

[33]ZhangX,WangYR,GongPT,et al.,2022.Neospora caninum evades immunityvia inducing host cell mitophagy to inhibit production of proinflammatory cytokines in a ROS-dependent manner.Front Immunol,13:827004.

[34]ZhangYF,YaoYK,QiuXX,et al.,2019.Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing.Nat Immunol,20(4):433-446.