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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2024-02-02
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Citations: Bibtex RefMan EndNote GB/T7714
https://orcid.org/0000-0001-8122-592X
Ahmad ALHASKAWI, Sohaib Hasan Abdullah EZZI, Yanzhao DONG, Haiying ZHOU, Zewei WANG, Jingtian LAI, Chengjun YAO, Vishnu Goutham KOTA, Mohamed Hasan Abdulla Hasan ABDULLA, Hui LU. Recent advancements in the diagnosis and treatment of acral melanoma[J]. Journal of Zhejiang University Science B, 2024, 25(2): 106-122.
@article{title="Recent advancements in the diagnosis and treatment of acral melanoma",
author="Ahmad ALHASKAWI, Sohaib Hasan Abdullah EZZI, Yanzhao DONG, Haiying ZHOU, Zewei WANG, Jingtian LAI, Chengjun YAO, Vishnu Goutham KOTA, Mohamed Hasan Abdulla Hasan ABDULLA, Hui LU",
journal="Journal of Zhejiang University Science B",
volume="25",
number="2",
pages="106-122",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300221"
}
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%J Journal of Zhejiang University SCIENCE B
%V 25
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%P 106-122
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%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300221
TY - JOUR
T1 - Recent advancements in the diagnosis and treatment of acral melanoma
A1 - Ahmad ALHASKAWI
A1 - Sohaib Hasan Abdullah EZZI
A1 - Yanzhao DONG
A1 - Haiying ZHOU
A1 - Zewei WANG
A1 - Jingtian LAI
A1 - Chengjun YAO
A1 - Vishnu Goutham KOTA
A1 - Mohamed Hasan Abdulla Hasan ABDULLA
A1 - Hui LU
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2300221
Abstract: acral melanoma (AM) is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate, largely due to the inconspicuous nature of early-stage lesions, which can lead to late diagnosis. Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas, early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities, including clinical examination, dermoscopy, histopathology, molecular testing, radiological imaging, and blood tests. While surgery is the preferred method of treatment for AM, other therapeutic options may be employed based on the stage and underlying etiology of the disease. Immune checkpoint inhibitors, molecular targeted therapy, radiotherapy, chemotherapy, and oncolytic virotherapy represent promising advanced treatment options for AM. In this review, we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM, highlighting the importance of early detection and the prompt, individualized management of this challenging disease.
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