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CLC number: R751.05

On-line Access: 2012-09-04

Received: 2012-04-22

Revision Accepted: 2012-08-09

Crosschecked: 2012-08-20

Cited: 5

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.9 P.745-750

http://doi.org/10.1631/jzus.B1200120


Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety


Author(s):  Xiao-hong Mao, Jian-you Wang, Jian-liang Yan

Affiliation(s):  Department of Dermatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   wangjianyou@medmail.com.cn

Key Words:  Infantile hemangioma (IH), Nevus flammeus (NF), Imiquimod, Treatment


Xiao-hong Mao, Jian-you Wang, Jian-liang Yan. Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety[J]. Journal of Zhejiang University Science B, 2012, 13(9): 745-750.

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%A Jian-you Wang
%A Jian-liang Yan
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%DOI 10.1631/jzus.B1200120

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T1 - Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety
A1 - Xiao-hong Mao
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VL - 13
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1200120


Abstract: 
Objective: To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients. Methods: A retrospective investigation was conducted in 25 pediatric patients with cutaneous vascular disorders, including 19 infantile hemangiomas (IHs) (12 superficial/7 mixed type), 5 nevus flammeus (NF), and 1 pyogenic granuloma (PG). imiquimod 5% cream was applied every other day for 4 to 16 weeks (average 9.6 weeks). Results: Of the 19 IHs treated, an overall efficacy of 52.6% was achieved, with a clinical resolution rate of 15.8%, excellent rate of 26.3%, and moderate rate of 10.5%. The superficial type responded the best at 66.7%, while the mixed type showed only 28.6% effectiveness, which was predominantly from their superficial parts. No obvious response was noted in the 5 patients with NF. Side effects were observed in 78.9% of the patients, mostly mild to moderate local irritations and occasionally severe reactions such as thick crusting and ulceration. Systemic side events were observed in 4 IH patients including fever and digestive tract reactions. No recurrence was observed during the follow-up examination. Conclusions: Topical imiquimod could be an alternative option for the treatment of uncomplicated superficial IHs with satisfactory tolerability.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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