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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300401


Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder


Author(s):  Weihao ZHENG, Qin ZHANG, Ziyang ZHAO, Pengfei ZHANG, Leilei ZHAO, Xiaomin WANG, Songyu YANG, Jing ZHANG, Zhijun YAO, Bin HU

Affiliation(s):  Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering, Lanzhou University, Lanzhou 730000, China; more

Corresponding email(s):   bh@lzu.edu.cn, yaozj@lzu.edu.cn, ery_zhangjing@lzu.edu.cn

Key Words:  Major depressive disorder, Resting-state functional magnetic resonance imaging, Thalamocortical circuitry, Dynamic functional connectivity, Dynamic laterality


Weihao ZHENG, Qin ZHANG, Ziyang ZHAO, Pengfei ZHANG, Leilei ZHAO, Xiaomin WANG, Songyu YANG, Jing ZHANG, Zhijun YAO, Bin HU. Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300401"
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%T Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder
%A Weihao ZHENG
%A Qin ZHANG
%A Ziyang ZHAO
%A Pengfei ZHANG
%A Leilei ZHAO
%A Xiaomin WANG
%A Songyu YANG
%A Jing ZHANG
%A Zhijun YAO
%A Bin HU
%J Journal of Zhejiang University SCIENCE B
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A1 - Ziyang ZHAO
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A1 - Leilei ZHAO
A1 - Xiaomin WANG
A1 - Songyu YANG
A1 - Jing ZHANG
A1 - Zhijun YAO
A1 - Bin HU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
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DOI - 10.1631/jzus.B2300401


Abstract: 
thalamocortical circuitry has a substantial impact on emotion and cognition. Previous studies have demonstrated alterations in thalamocortical functional connectivity (FC), characterized by region-dependent hypo- or hyper-connectivity, among individuals with major depressive disorder (MDD). However, the dynamical reconfiguration of the thalamocortical system over time and potential abnormalities in dynamic thalamocortical connectivity associated with MDD remain unclear. Hence, we analyzed dynamic FC (dFC) between ten thalamic subregions and seven cortical subnetworks from resting-state functional magnetic resonance images of 48 patients with MDD and 57 healthy controls (HCs) to investigate time-varying changes in thalamocortical FC in patients with MDD. Moreover, dynamic laterality analysis was conducted to examine the changes in functional lateralization of the thalamocortical system over time. Correlations between the dynamic measures of thalamocortical FC and clinical assessment were also calculated. We identified four dynamic states of thalamocortical circuitry wherein patients with MDD exhibited decreased fractional time and reduced transitions within a negative connectivity state that showed strong correlations with primary cortical networks, compared with the HCs. In addition, MDD patients also exhibited increased fluctuations in functional laterality in the thalamocortical system across the scan duration. The thalamo-subnetwork analysis unveiled abnormal dFC variability involving higher-order cortical networks in the MDD cohort. Significant correlations were found between increased dFC variability with dorsal attention and default mode networks and the severity of symptoms. Our study comprehensively investigated the pattern of alteration of the thalamocortical dFC in MDD patients. The heterogeneous alterations of dFC between the thalamus and both primary and higher-order cortical networks may help characterize the deficits of sensory and cognitive processing in MDD.

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