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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300641


ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis


Author(s):  Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM

Affiliation(s):  Department of Biological Sciences & Biotechnology, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, Selangor, Malaysia; more

Corresponding email(s):   sylvia@ukm.edu.my

Key Words:  ABC transporters, Bacterial pathogenesis, Virulence


Shu Sian HOW, Sylvia CHIENG, Sheila NATHAN, Su Datt LAM. ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
ATP-binding cassette (ABC) transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer, against the concentration gradient. These transporters comprise two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Unlike ABC exporters, prokaryotic ABC importers require an additional substrate-binding protein (SBP) as a recognition site for specific substrate translocation. The discovery of a large number of ABC systems in bacterial pathogens revealed that these transporters are crucial for the establishment of bacterial infections. The existing literature has highlighted the roles of ABC transporters in bacterial growth, pathogenesis, and virulence. These roles include importing essential nutrients required for a variety of cellular processes and exporting outer membrane-associated virulence factors and antimicrobial substances. This review outlines the general structures and classification of ABC systems to provide a comprehensive view of the activities and roles of ABC transporters associated with bacterial virulence and pathogenesis during infection.

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