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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300743


Prefrontal cortical circuits in social behaviors: an overview


Author(s):  Wei CAO, Huiyi LI, Jianhong LUO

Affiliation(s):  Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China; more

Corresponding email(s):   luojianhong@zju.edu.cn

Key Words:  Prefrontal cortex, Social behaviors, Autism spectrum disorder, Schizophrenia, Parvalbumin-positive interneurons, NMDA receptors


Wei CAO, Huiyi LI, Jianhong LUO. Prefrontal cortical circuits in social behaviors: an overview[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
social behaviors are fundamental and intricate functions in both humans and animals, governed by the interplay of social cognition and emotions. A noteworthy feature of several neuropsychiatric disorders, including autism spectrum disorders (ASD) and schizophrenia (SCZ), is a pronounced deficit in social functioning. Despite a burgeoning body of research on social behaviors, the precise neural circuit mechanisms underpinning these phenomena remain to be elucidated. In this paper, we review the pivotal role of the prefrontal cortex (PFC) in modulating social behaviors, as well as its functional alteration in social disorders in ASD or SCZ. We posit that PFC dysfunction may represent a critical hub in the pathogenesis of psychiatric disorders characterized by shared social deficits. Furthermore, we delve into the intricate connectivity of the mPFC with other cortical areas and subcortical brain regions in rodents, which exerts a profound influence on social behaviors. Notably, a substantial body of evidence underscores the role of N-methyl-D-aspartate (NMDA) receptors and the proper functioning of parvalbumin-positive interneurons within the mPFC for social regulation. Our overarching goal is to furnish a comprehensive understanding of these intricate circuits, and thereby contribute to the enhancement of both research endeavors and clinical practices concerning social behavior deficits.

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