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Fibroblast growth factors and endometrial decidualization: models, mechanisms and related pathologies
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Xueni ZHANG, Yidi MO, Chunbin LU, Zhijian SU, Xiaokun LI. Fibroblast growth factors and endometrial decidualization: models, mechanisms and related pathologies[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Fibroblast growth factors and endometrial decidualization: models, mechanisms and related pathologies",
author="Xueni ZHANG, Yidi MO, Chunbin LU, Zhijian SU, Xiaokun LI",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300830"
}
%0 Journal Article
%T Fibroblast growth factors and endometrial decidualization: models, mechanisms and related pathologies
%A Xueni ZHANG
%A Yidi MO
%A Chunbin LU
%A Zhijian SU
%A Xiaokun LI
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300830
TY - JOUR
T1 - Fibroblast growth factors and endometrial decidualization: models, mechanisms and related pathologies
A1 - Xueni ZHANG
A1 - Yidi MO
A1 - Chunbin LU
A1 - Zhijian SU
A1 - Xiaokun LI
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300830
Abstract: The onset of pregnancy is marked by the formation of a zygote, while the culmination of gestation is manifested by the delivery of a fetus. Meanwhile, a successful pregnancy entails a meticulously coordinated sequence of events from embryo implantation to sustained decidualization of the uterus to placental development and childbirth. The decidual reaction, a pivotal process occurring within the endometrium during pregnancy, is finely regulated by sex steroids and cytokines. Notably, fibroblast growth factor (FGF), particularly FGF-2, assumes a critical role in this physiological cascade. Dysregulated FGF expression may trigger inadequate decidualization, precipitating a spectrum of adverse pregnancy outcomes, including preeclampsia, recurrent implantation failures, and miscarriage. Furthermore, the human decidua, distinct from most mammalian species and similar to great apes, undergoes regular cycles of formation and shedding, independent of embryo presence in the endometrium. This process is also tightly controlled by various FGFs. In this review, we comprehensively compare diverse research decidualization models, delineate the regulatory mechanisms of FGFs in decidualization, and provide a synopsis of endometrial diseases triggered by FGF dysregulation.
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