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Bio-Design and Manufacturing  2022 Vol.5 No.1 P.153-162

http://doi.org/10.1007/s42242-021-00143-6


Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor


Author(s):  Yafeng Jing, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Xuefang Zheng, Hongyu Cao & Shuo Bai

Affiliation(s):  College of Life Science and Biotechnology, Dalian University, Dalian, 116622, China; more

Corresponding email(s):   ahwang@ipe.ac.cn, caohongyu@foxmail.com, baishuo@ipe.ac.cn

Key Words:  Conductivity, Transparency, Peptide hydrogel, Polypyrrole-polydopamine nanoparticles, Wearable biosensor


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Yafeng Jing, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Xuefang Zheng, Hongyu Cao & Shuo Bai. Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor[J]. Journal of Zhejiang University Science D, 2022, 5(1): 153-162.

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author="Yafeng Jing, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Xuefang Zheng, Hongyu Cao & Shuo Bai",
journal="Journal of Zhejiang University Science D",
volume="5",
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pages="153-162",
year="2022",
publisher="Zhejiang University Press & Springer",
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Abstract: 
Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility, multi-functionality, and physiochemical properties similar to those of body tissues. However, the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process difficult. To overcome this issue, hydrophilic conductive polydopamine (PDA)-doped polypyrrole (PPy) nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel networks. This technique creates a complete conductive network and allows visible light to pass through. The strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency, but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection, as evidenced by the experimental data.

中科院过程工程研究所白硕等 | 导电透明二肽水凝胶的制备及用于可穿戴生物传感器

本研究论文聚焦导电透明二肽水凝胶的制备及用于可穿戴生物传感器。导电透明短肽水凝胶由于具有优异的生物相容性、多功能性及类似于人体组织粘弹性质而成为制备柔性电子器件和可穿戴生物传感器的理想材料。但导电掺杂材料的疏水性使其在凝胶中很难均匀分散,因此制备具有高导电性和透明性的短肽水凝胶依然是一个巨大的挑战。为了解决上述问题,作者一方面采用亲水性聚多巴胺(PDA)修饰聚吡咯(PPy)导电纳米颗粒并引入到短肽水凝胶网络中,另一方面利用自由基对此纳米颗粒的分解作用结合凝胶网络的模板作用,促使导电聚吡咯纳米纤维的形成,制备了全新的导电网络,并允许可见光通过。实验数据表明,该方法不仅赋予了二肽水凝胶良好的导电性和高透明性,而且为导电二肽水凝胶在人体粘附信号检测方面提供了广阔的应用前景。

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