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Time-space regulation of biomimetic vascularization in 3D printed skeletal muscles
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Minxuan Jia,Tingting Fan,Tan Jia,Xin Liu,Heng Liu,and Qi Gu. Time-space regulation of biomimetic vascularization in 3D printed skeletal muscles[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Time-space regulation of biomimetic vascularization in 3D printed skeletal
muscles",
author="Minxuan Jia,Tingting Fan,Tan Jia,Xin Liu,Heng Liu,and Qi Gu",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
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year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-BDMJ-D-23-00272"
}
%0 Journal Article
%T Time-space regulation of biomimetic vascularization in 3D printed skeletal
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%A Minxuan Jia
%A Tingting Fan
%A Tan Jia
%A Xin Liu
%A Heng Liu
%A and Qi Gu
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-BDMJ-D-23-00272
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T1 - Time-space regulation of biomimetic vascularization in 3D printed skeletal
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A1 - Minxuan Jia
A1 - Tingting Fan
A1 - Tan Jia
A1 - Xin Liu
A1 - Heng Liu
A1 - and Qi Gu
J0 - Journal of Zhejiang University Science D
VL - -1
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1007/s42242-BDMJ-D-23-00272
Abstract: In the intricate skeletal muscle tissue, the symbiotic relationship between myotubes and their supporting
vasculature is pivotal in delivering essential oxygen and nutrients. This study delves deep into the nuanced
interplay between skeletal muscle cells and endothelial cells in the vascularization of muscle tissue. By harnessing
the capabilities of 3D bioprinting and modeling, we employed a groundbreaking approach: co-constructing
endothelial and muscle cells, followed by their subsequent differentiation. Our findings underscore the profound
impact of the interaction dynamics between these two cell types. Notably, introducing endothelial cells during the
advanced phases of muscle differentiation enhanced myotube assembly. It spurred the development of the vascular
network, paving the way for the early stages of vascularized skeletal muscle. The methodology highlighted in this
research illuminates the potential for creating large-scale, physiologically aligned skeletal muscle. Furthermore,
it accentuates the need for deeper explorations into the delicate equilibrium and mutual interactions between
muscle and endothelial cells. Guided by the multi-cell-type interaction model, we foresee promising pathways for
crafting even more intricate tissues or organs.
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