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On-line Access: 2025-11-14
Received: 2025-02-19
Revision Accepted: 2025-05-26
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Multiorgan-on-a-chip: an advanced platform for disease modeling, drug toxicity assessment, and therapeutic screening
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Li Qiao (??), Shiqi Chang (???), Lin Zou (??), Feng Zhang (??), Chang Cui (??) & Ningping Huang (???) . Multiorgan-on-a-chip: an advanced platform for disease modeling, drug toxicity assessment, and therapeutic screening[J]. Journal of Zhejiang University Science D, 2025, 8(6): 1035-1062.
@article{title="Multiorgan-on-a-chip: an advanced platform for disease modeling, drug toxicity assessment, and therapeutic screening",
author="Li Qiao (??), Shiqi Chang (???), Lin Zou (??), Feng Zhang (??), Chang Cui (??) & Ningping Huang (???) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="6",
pages="1035-1062",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500076"
}
%0 Journal Article
%T Multiorgan-on-a-chip: an advanced platform for disease modeling, drug toxicity assessment, and therapeutic screening
%A Li Qiao (??)
%A Shiqi Chang (???)
%A Lin Zou (??)
%A Feng Zhang (??)
%A Chang Cui (??) & Ningping Huang (???)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 6
%P 1035-1062
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500076
TY - JOUR
T1 - Multiorgan-on-a-chip: an advanced platform for disease modeling, drug toxicity assessment, and therapeutic screening
A1 - Li Qiao (??)
A1 - Shiqi Chang (???)
A1 - Lin Zou (??)
A1 - Feng Zhang (??)
A1 - Chang Cui (??) & Ningping Huang (???)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 6
SP - 1035
EP - 1062
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500076
Abstract: Multiorgan-on-a-chip (MOoC) systems are advanced microfluidic devices that integrate multiple organ models into a single
modular unit, each composed of cells derived from various tissues or organs. These systems enable interorgan communica
tion and accurately replicate physiological conditions, providing a more physiologically relevant modeling framework for
constructing disease models and predicting drug efficacy and toxicity. MOoC systems also provide significant advantages in
terms of flexibility, cost-effectiveness, and reproducibility, making them valuable tools for drug development and toxicity as
sessment. In this review, we first provide an overview of the MOoC technology, covering cell sources, stimulations, materi
als and fabrication techniques, and biosensors. We then examine the application of MOoC systems in disease modeling, fo
cusing on cancer metastasis, metabolic disorders, and cardiovascular disease. We next discuss the use of MOoC systems in
drug toxicity evaluation and drug screening, emphasizing their role in providing comprehensive assessments of drug effects.
Finally, we address the challenges it faces and the future perspectives of the MOoC technology.
Open peer comments: Debate/Discuss/Question/Opinion
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