
Yan Wang, Jin Wu, Shicheng Li, Rencai Fan, Mingjun Li, Xin Liu, Cheng-song Yuan, Yuanyuan Chang, Zequn Ma, Chunxian Guo, Chang Ming Li, Bo Chen. Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy[J]. Journal of Zhejiang University Science D, 2026, 9(5): 845 - 867.
@article{title="Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy",
author="Yan Wang, Jin Wu, Shicheng Li, Rencai Fan, Mingjun Li, Xin Liu, Cheng-song Yuan, Yuanyuan Chang, Zequn Ma, Chunxian Guo, Chang Ming Li, Bo Chen",
journal="Journal of Zhejiang University Science D",
volume="9",
number="5",
pages="845 - 867",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2600068"
}
%0 Journal Article
%T Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy
%A Yan Wang
%A Jin Wu
%A Shicheng Li
%A Rencai Fan
%A Mingjun Li
%A Xin Liu
%A Cheng-song Yuan
%A Yuanyuan Chang
%A Zequn Ma
%A Chunxian Guo
%A Chang Ming Li
%A Bo Chen
%J Journal of Zhejiang University SCIENCE D
%V 9
%N 5
%P 845 - 867
%@ 1869-1951
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2600068
TY - JOUR
T1 - Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy
A1 - Yan Wang
A1 - Jin Wu
A1 - Shicheng Li
A1 - Rencai Fan
A1 - Mingjun Li
A1 - Xin Liu
A1 - Cheng-song Yuan
A1 - Yuanyuan Chang
A1 - Zequn Ma
A1 - Chunxian Guo
A1 - Chang Ming Li
A1 - Bo Chen
J0 - Journal of Zhejiang University Science D
VL - 9
IS - 5
SP - 845
EP - 867
%@ 1869-1951
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2600068
Abstract: Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and endogenous stimuli to trigger ROS bursts, as well as chirality-enhanced tumor microenvironment (TME) penetration, offers a valid solution. We developed a stimuli-responsive nanoreactor by coupling chiral histidine-modified manganese ferrite (MnFe2O4-PEG) nanoparticles with chiral cysteine-modified black phosphorus (BP) nanosheets via an ROS-sensitive thioketal (TK) bond to form a MnFe2O4-BP chiral magnetic nanoreactor (CT-MFBP). L-MFBP exhibited superior cellular uptake and intracellular retention due to its enhanced affinity for cell membranes. After entering the TME, the thioketal bond was cleaved by alternating magnetic field (AMF)-induced ROS, leading to the decomposition of the nanoreactor into chiral BP components. Subsequently, ROS accumulation was further amplified using BP-mediated photodynamic therapy (PDT). In addition, the nanoreactor demonstrated catalase (CAT)-like activity, converting endogenous H2O2 into O2, thereby effectively alleviating the tumor hypoxic microenvironment and enhancing PDT efficacy. Furthermore, these events activated the mitogen-activated protein kinase (MAPK)-caspase 3 signaling pathway by upregulating p38 protein and Bcl-2-modifying factor (BMF) expression, which together promoted anoikis in tumor cells—a finding further validated by genomic analysis. Both in vitro and in vivo results confirmed that L-MFBP provides a robust regulatory strategy to induce anoikis and suppress tumor metastasis, offering a promising approach for chiral magnetic nanomedicine in clinical antitumor applications.
CLC number:
On-line Access: 2026-09-16
Received: 2026-01-29
Revision Accepted: 2026-05-09
Crosschecked: 0000-00-00
Cited:
Clicked: 53
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