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Abstract: obesity has been reported to be associated with many diseases. However, common obesity-induced biological processes have not been evaluated across these diseases. We identified genes associated with obesity and obesity-related diseases, and used them to construct protein‒protein interaction networks. We also analyzed gene ontology (GO) in those genes overlapping between obesity and disease. Our work identifies gene modules common to obesity and obesity-related diseases, which can provide a basis for understanding the process of how obesity induces disease.

网络分析筛选六种与肥胖相关疾病的共同的肥胖基因

[1]An, O., Dall'Olio, G.M., Mourikis, T.P., et al., 2016. NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings. Nucleic Acids Res., 44(D1):D992-D999.

[2]Assenov, Y., Ramírez, F., Schelhorn, S.E., et al., 2008. Computing topological parameters of biological networks. Bioinformatics, 24(2):282-284.

[3]Blackburn, G.L., Wang, K.A., 2007. Dietary fat reduction and breast cancer outcome: results from the Women’s Intervention Nutrition Study (WINS). Am. J. Clin. Nutr., 86(3):878S-881S.

[4]Boffetta, P., Hashibe, M., la Vecchia, C., et al., 2006. The burden of cancer attributable to alcohol drinking. Int. J. Cancer, 119(4):884-887.

[5]Dai, H.J., Wu, J.C., Tsai, R.T., et al., 2013. T-HOD: a literature-based candidate gene database for hypertension, obesity and diabetes. Database, 2013:bas061.

[6]Eckel, N., Meidtner, K., Kalle-Uhlmann, T., et al., 2016. Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis. Eur. J. Prev. Cardiol., 23(9):956-966.

[7]Gao, H.H., Gao, L.B., Wen, J.M., 2014. Genetic polymorphisms in the ESR1 gene and cerebral infarction risk: a meta-analysis. DNA Cell Biol., 33(9):605-615.

[8]Gao, Y., Huang, Y., Song, F., et al., 2016. Urban-rural disparity of overweight/obesity distribution and its potential trend with breast cancer among Chinese women. Oncotarget, 7(35):56608-56618.

[9]Gateva, A.T., Kamenov, Z.A., 2012. Markers of visceral obesity and cardiovascular risk in patients with polycystic ovarian syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol., 164(2):161-166.

[10]Gateva, A., Kamenov, Z., Tsakova, A., 2013. NT-proBNP levels in premenopausal women with polycystic ovarian syndrome and/or obesity. J. Obstet. Gynaecol., 33(8):868-872.

[11]Hancock, S.B., Georgiades, C.S., 2016. Kidney cancer. Cancer J., 22(6):387-392.

[12]Hwang, J.Y., Lee, H.J., Go, M.J., et al., 2016. An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population. Sci. Rep., 6:33043.

[13]Jiang, N., Yang, G., Peng, C.L., 2015. ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk. Genet. Mol. Res., 14(4):13932-13944.

[14]Johnson, K.C., Miller, A.B., Collishaw, N.E., et al., 2011. Active smoking and secondhand smoke increase breast cancer risk: the report of the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk (2009). Tob. Control, 20(1):e2.

[15]Kaiser, J., 2013. Cholesterol forges link between obesity and breast cancer. Science, 342(6162):1028.

[16]Kivimäki, P.M., Nyberg, S.T., Batty, G.D., et al., 2012. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet, 380(9852):1491-1497.

[17]Kohl, M., Wiese, S., Warscheid, B., 2011. Cytoscape: software for visualization and analysis of biological networks. In: Hamacher, M., Eisenacher, M., Stephan, C. (Eds.), Data Mining in Proteomics. Methods in Molecular Biology (Methods and Protocols), Vol. 696. Humana Press, p.291-303.

[18]Kumar, N., Afeyan, R., Sheppard, S., et al., 2007. Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment. Biochem. Biophys. Res. Commun., 354(1):14-20.

[19]Lackland, D.T., Weber, M.A., 2015. Global burden of cardiovascular disease and stroke: hypertension at the core. Can. J. Cardiol., 31(5):569-571.

[20]Linnér, C., Svartberg, J., Giwercman, A., et al., 2013. Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men. Aging Male, 16(2):52-57.

[21]Liu, H., Liu, W., Liao, Y., et al., 2011. CADgene: a comprehensive database for coronary artery disease genes. Nucleic Acids Res., 39(suppl_1):D991-D996.

[22]Mehta, P.K., Wei, J., Wenger, N.K., 2015. Ischemic heart disease in women: a focus on risk factors. Trends Cardiovasc. Med., 25(2):140-151.

[23]Moran, L.J., Ko, H., Misso, M., et al., 2013. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. Hum. Reprod. Update, 19(5):432.

[24]Nafiye, Y., Sevtap, K., Muammer, D., et al., 2010. The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome. Fertil. Steril., 93(6):1864-1869.

[25]Nagrani, R., Mhatre, S., Rajaraman, P., et al., 2016. Central obesity increases risk of breast cancer irrespective of menopausal and hormonal receptor status in women of South Asian Ethnicity. Eur. J. Cancer, 66:153-161.

[26]Poulter, N.R., Prabhakaran, D., Caulfield, M., 2015. Hypertension. Lancet, 386(9995):801-812.

[27]Rogge, B.P., Cramariuc, D., Lønnebakken, M.T., et al., 2013. Effect of overweight and obesity on cardiovascular events in asymptomatic aortic stenosis: a SEAS substudy (Simvastatin Ezetimibe in Aortic Stenosis). J. Am. Coll. Cardiol., 62(18):1683-1690.

[28]Sarwar, N., Gao, P., Kondapally Seshasai, S.R., et al., 2010. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet, 375(9733):2215-2222.

[29]Sherman, B.T., Huang, D.W., Tan, Q., et al., 2007. DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics, 8:426.

[30]Snel, B., Lehmann, G., Bork, P., et al., 2000. STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res., 28(18):3442-3444.

[31]Vilarrasa, N., Rubio, M.A., Miñambres, I., et al., 2017. Long-term outcomes in patients with morbid obesity and type 1 diabetes undergoing bariatric surgery. Obes. Surg., 27(4):856-863.

[32]Wilson, K.M., Cho, E., 2016. Obesity and kidney cancer. In: Pischon, T., Nimptsch, K. (Eds.), Obesity and Cancer. Recent Results in Cancer Research, Vol. 208. Springer, Cham., p.81-93.

[33]Zhang, G., Liu, Z., Xu, H., et al., 2016. miR-409-3p suppresses breast cancer cell growth and invasion by targeting Akt1. Biochem. Biophys. Res. Commun., 469(2):189-195.

[34]Zhang, Y., Zhang, M., Yuan, X., et al., 2015. Association between ESR1 PvuII, XbaI, and P325P polymorphisms and breast cancer susceptibility: a meta-analysis. Med. Sci. Monit., 21:2986-2996.