JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.7 P.613-616

http://doi.org/10.1631/jzus.B1900018

Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats

Author(s): Chang-Hui Zhao, Chao Zhao, Hai-Qing Ye, Chun-Yu Xi, Zheng-Ping Zou, Xin-Hui Zhou, Ping-Ping Hou, Tie-Hua Zhang
Affiliation(s): College of Food Science and Engineering, Jilin University, Changchun 130062, China
Corresponding email(s): zhangth@jlu.edu.cn
Key Words: Ovum oil of Rana chensinensis, Forest frog, Hyperlipidemia

Share this article to： More <<< Previous Article \|

Chang-Hui Zhao, Chao Zhao, Hai-Qing Ye, Chun-Yu Xi, Zheng-Ping Zou, Xin-Hui Zhou, Ping-Ping Hou, Tie-Hua Zhang. Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats[J]. Journal of Zhejiang University Science B, 2019, 20(7): 613-616.

@article{title="Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats",
author="Chang-Hui Zhao, Chao Zhao, Hai-Qing Ye, Chun-Yu Xi, Zheng-Ping Zou, Xin-Hui Zhou, Ping-Ping Hou, Tie-Hua Zhang",
journal="Journal of Zhejiang University Science B",
volume="20",
number="7",
pages="613-616",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900018"
}

%0 Journal Article
%T Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats
%A Chang-Hui Zhao
%A Chao Zhao
%A Hai-Qing Ye
%A Chun-Yu Xi
%A Zheng-Ping Zou
%A Xin-Hui Zhou
%A Ping-Ping Hou
%A Tie-Hua Zhang
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 7
%P 613-616
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900018

TY - JOUR
T1 - Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats
A1 - Chang-Hui Zhao
A1 - Chao Zhao
A1 - Hai-Qing Ye
A1 - Chun-Yu Xi
A1 - Zheng-Ping Zou
A1 - Xin-Hui Zhou
A1 - Ping-Ping Hou
A1 - Tie-Hua Zhang
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 7
SP - 613
EP - 616
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900018

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The ovum oil of forest frog has various health beneficial functions. In the current research, we evaluated the hypolipidemic effects of the low-cholesterol ovum oil from the forest frog and its combination with stigmasterol in rats.

低胆固醇林蛙卵油和植物甾醇(豆甾醇)在大鼠中的降脂作用

目的:探索林蛙副产物林蛙卵油的开发价值.
创新点:首次验证了低胆固醇林蛙卵油的减重降脂功能.
方法:Sprague-Dawley大鼠连续被灌胃8周后,分成8组:(1)对照组喂食标准饲料;(2)高脂组喂食60%高脂饲料;(3)阳性对照组喂食3.33 mg/(kg·d)辛伐他汀;(4)OORC组喂食2 g/(kg·d)的低胆固醇林蛙卵油(OORC);(5)植物甾醇组喂食 0.48 g/(kg·d)的豆甾醇;(6)低剂量组喂食1 g/(kg·d)的低胆固醇OORC和0.24 g/(kg·d)的豆甾醇;(7)中剂量组喂食2 g/(kg·d)的低胆固醇OORC和0.48 g/(kg·d)的豆甾醇;(8)高剂量组喂食4 g/(kg·d)的低胆固醇OORC 和0.96 g/(kg·d)的豆甾醇.经过不同方法处理后,比较各组大鼠的体重、器官指数,以及血清中总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白浓度.同时,对动物肝脏进行组织切片染色并评价损伤情况.
结论:低胆固醇林蛙卵油或者其与植物甾醇(如豆甾醇)联用可以预防高脂饮食诱导的增重、肝损伤和高血脂症状.
关键词：林蛙卵油;林蛙;肥胖;高血脂

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Bahmani M, Mirhoseini M, Shirzad H, et al., 2015. A review on promising natural agents effective on hyperlipidemia. J Evid Based Complementary Altern Med, 20(3):228-238.

[2]Bao Y, Jiang W, Liu D, et al., 2016. Advances in pharmacological research of Chinese forest frog. Mod Chin Med, 18(8):1077-1080 (in Chinese).

[3]https://doi.org/10.13313/j.issn.1673-4890.2016.8.031

[4]Chen JT, Wesley R, Shamburek RD, et al., 2005. Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy, 25(2):171-183.

[5]Cholesterol Treatment Trialists’ (CTT) Collaboration, 2015. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials. Lancet, 385(9976):1397-1405.

[6]Ji XF, Lin F, Qiu FP, 2013. Optimization on aqueous enzymatic extraction conditions of forest frog egg protein by response surface method. J Changchun Univ Technol (Nat Sci Ed), 34(2):137-144 (in Chinese).

[7]Jin LL, Wang QY, Lou H, et al., 2004. The analysis and research of components of fatty acid in the ovum oil of Rana chensinensis. Food Sci, 25(10):232-234 (in Chinese).

[8]Nelson RH, 2013. Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care, 40(1):195-211.

[9]Park Y, Carr TP, 2013. Unsaturated fatty acids and phytosterols regulate cholesterol transporter genes in Caco-2 and HepG2 cell lines. Nutrit Res, 33(2):154-161.

[10]Wang ZY, Zhao YY, Su TT, et al., 2015. Characterization and antioxidant activity in vitro and in vivo of polysaccharide purified from Rana chensinensis skin. Carbohydr Polym, 126:17-22.

[11]Yu L, Morishima C, Ioannou GN, 2013. Dietary cholesterol intake is associated with progression of liver disease in patients with chronic hepatitis C: analysis of the hepatitis C antiviral long-term treatment against cirrhosis trial. Clin Gastroenterol Hepatol, 11(12):1661-1666.

[12]Zhang T, Zhao C, Zhao C, et al., 2019. Optimization of conditions for cholesterol removal from Rana chensinensis ovum oil. Curr Topics Nutraceut Res, 17(2):135-139.

[13]List of electronic supplementary materials

[14]Data S1 Materials and methods

[15]Table S1 Organ indices of the rats in different groups

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Similar articles

- Go to

低胆固醇林蛙卵油和植物甾醇(豆甾醇)在大鼠中的降脂作用

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference