CLC number:
On-line Access: 2023-03-10
Received: 2022-07-19
Revision Accepted: 2022-12-07
Crosschecked: 2023-03-13
Cited: 0
Clicked: 1101
Citations: Bibtex RefMan EndNote GB/T7714
Xuwentai LIU, Yue WU, Yanyi LI, Kaiming LI, Siyuan HOU, Ming DING, Jingmin TAN, Zijing ZHU, Yingqi TANG, Yuming LIU, Qianhui SUN, Cong WANG, Can ZHANG. Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)[J]. Journal of Zhejiang University Science B, 2023, 24(3): 248-261.
@article{title="Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)",
author="Xuwentai LIU, Yue WU, Yanyi LI, Kaiming LI, Siyuan HOU, Ming DING, Jingmin TAN, Zijing ZHU, Yingqi TANG, Yuming LIU, Qianhui SUN, Cong WANG, Can ZHANG",
journal="Journal of Zhejiang University Science B",
volume="24",
number="3",
pages="248-261",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200383"
}
%0 Journal Article
%T Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)
%A Xuwentai LIU
%A Yue WU
%A Yanyi LI
%A Kaiming LI
%A Siyuan HOU
%A Ming DING
%A Jingmin TAN
%A Zijing ZHU
%A Yingqi TANG
%A Yuming LIU
%A Qianhui SUN
%A Cong WANG
%A Can ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 3
%P 248-261
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200383
TY - JOUR
T1 - Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)
A1 - Xuwentai LIU
A1 - Yue WU
A1 - Yanyi LI
A1 - Kaiming LI
A1 - Siyuan HOU
A1 - Ming DING
A1 - Jingmin TAN
A1 - Zijing ZHU
A1 - Yingqi TANG
A1 - Yuming LIU
A1 - Qianhui SUN
A1 - Cong WANG
A1 - Can ZHANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 3
SP - 248
EP - 261
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200383
Abstract: An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism. hepatic fibrosis is characterized by activated hepatic stellate cells (aHSCs) with an excessive production of extracellular matrix. Although promoted activation of HSCs by M2 macrophages has been demonstrated, the molecular mechanism involved remains ambiguous. Herein, we propose that the vitamin D receptor (VDR) involved in macrophage polarization may regulate the communication between macrophages and HSCs by changing the functions of exosomes. We confirm that activating the VDR can inhibit the effect of M2 macrophages on HSC activation. The exosomes derived from M2 macrophages can promote HSC activation, while stimulating VDR alters the protein profiles and reverses their roles in M2 macrophage exosomes. smooth muscle cell-associated protein 5 (SMAP-5) was found to be the key effector protein in promoting HSC activation by regulating autophagy flux. Building on these results, we show that a combined treatment of a VDR agonist and a macrophage-targeted exosomal secretion inhibitor achieves an excellent anti-hepatic fibrosis effect. In this study, we aim to elucidate the association between VDR and macrophages in HSC activation. The results contribute to our understanding of the pathogenesis mechanism of hepatic fibrosis, and provide potential therapeutic targets for its treatment.
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