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TAF1 aggravates ferroptosis by promoting ubiquitin-mediated degradation of nGPX4
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Kehong YE1,2, Meifu GAN3, Liang SUN1, Chaoyi CHEN4, Xuan LAI1, Yinjun HE5, Ming ZHU1, Weiqin JIANG6, Honghe ZHANG1. TAF1 aggravates ferroptosis by promoting ubiquitin-mediated degradation of nGPX4[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="TAF1 aggravates ferroptosis by promoting ubiquitin-mediated degradation of nGPX4",
author="Kehong YE1,2, Meifu GAN3, Liang SUN1, Chaoyi CHEN4, Xuan LAI1, Yinjun HE5, Ming ZHU1, Weiqin JIANG6, Honghe ZHANG1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500567"
}
%0 Journal Article
%T TAF1 aggravates ferroptosis by promoting ubiquitin-mediated degradation of nGPX4
%A Kehong YE1
%A 2
%A Meifu GAN3
%A Liang SUN1
%A Chaoyi CHEN4
%A Xuan LAI1
%A Yinjun HE5
%A Ming ZHU1
%A Weiqin JIANG6
%A Honghe ZHANG1
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500567
TY - JOUR
T1 - TAF1 aggravates ferroptosis by promoting ubiquitin-mediated degradation of nGPX4
A1 - Kehong YE1
A1 - 2
A1 - Meifu GAN3
A1 - Liang SUN1
A1 - Chaoyi CHEN4
A1 - Xuan LAI1
A1 - Yinjun HE5
A1 - Ming ZHU1
A1 - Weiqin JIANG6
A1 - Honghe ZHANG1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500567
Abstract: glutathione peroxidase 4 (GPX4) is a primary inhibitor of ferroptosis, a regulated form of cell death driven by the accumulation of lipid hydroperoxides. GPX4 exists in three isoforms localized in the cytosol, mitochondria and nucleus, respectively; however, the regulatory mechanisms governing nuclear GPX4 (nGPX4) remain largely unclear. Herein, we identified TATA-box binding protein-associated factor 1 (TAF1) as a pivotal regulator of nGPX4. TAF1 phosphorylates nGPX4, leading to its K11-linked ubiquitination and proteasomal degradation, thereby promoting ferroptosis in p53-mutant cells. Conversely, in p53-wild-type cells, TAF1 phosphorylates p53, facilitating MDM2 proto-oncogene (MDM2)-mediated p53 degradation, which upregulates solute carrier family 7 member 11 (SLC7A11) expression and reduces cellular susceptibility to ferroptosis. Collectively, TAF1 plays dual and context-dependent roles in ferroptosis regulation, acting as both a promoter and inhibitor depending on the p53 status.
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