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Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats
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ZhiyongZeng,GuohuaJiang,TianqiLiu, GaoSong,YanfangSun, XueyaZhang, YantingJing,MingjiaFeng,YufeiShi. Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats[J]. Journal of Zhejiang University Science D, 2021, 4(4): 902-911.
@article{title="Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats",
author="ZhiyongZeng,GuohuaJiang,TianqiLiu, GaoSong,YanfangSun, XueyaZhang, YantingJing,MingjiaFeng,YufeiShi",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="902-911",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00140-9"
}
%0 Journal Article
%T Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats
%A ZhiyongZeng
%A GuohuaJiang
%A TianqiLiu
%A GaoSong
%A YanfangSun
%A XueyaZhang
%A YantingJing
%A MingjiaFeng
%A YufeiShi
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 902-911
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00140-9
TY - JOUR
T1 - Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats
A1 - ZhiyongZeng
A1 - GuohuaJiang
A1 - TianqiLiu
A1 - GaoSong
A1 - YanfangSun
A1 - XueyaZhang
A1 - YantingJing
A1 - MingjiaFeng
A1 - YufeiShi
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 902
EP - 911
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00140-9
Abstract: Injection therapy for diabetes has poor patient compliance, and the painoccurring at the site of subcutaneous injections
causes signifcant inconvenience to diabetic patients. In this work, to demonstrate the benefts of an alternative drug delivery
technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin
were developed to adjust blood glucose levels in diabetic rats. Gelatin methacryloyl microneedles (GelMA-MNs) with dif-ferent degrees of substitution were successfully prepared by a micro-molding method. The resultant GelMA-MNs exhibited
excellent mechanical properties and moisture resistance. Metformin, an anti-diabetic drug, was further encapsulated into
the GelMA-MNs, and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,
thereby exhibiting sustained drug release behaviors invitro and implying a better therapeutic efect compared with that of
subcutaneous injection in diabetic rats. The drug release period could be signifcantly prolonged by improving the cross-link density of GelMA-MNs. The results of hypoglycemic efect evaluation show that the application of GelMA-MNs for
transdermal delivery in diabetic rats has promising benefts for diabetes treatment.
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