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CLC number: R542.2

On-line Access: 2015-05-04

Received: 2014-07-21

Revision Accepted: 2015-03-12

Crosschecked: 2015-04-09

Cited: 13

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Citations:  Bibtex RefMan EndNote GB/T7714


Hai-tao Yu


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.344-354


Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats

Author(s):  Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu

Affiliation(s):  Department of Cardiovascular Medicine, the First Hospital of Jilin University, Changchun 130021, China; more

Corresponding email(s):   tedyu@foxmail.com, suishengwu@gmail.com

Key Words:  Ginsenoside Rg1, Diabetic cardiomyopathy, Oxidative stress, Apoptosis, Caspase-3 (CASP3)

Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats[J]. Journal of Zhejiang University Science B, 2015, 16(5): 344-354.

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author="Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats
%A Hai-tao Yu
%A Juan Zhen
%A Bo Pang
%A Jin-ning Gu
%A Sui-sheng Wu
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 5
%P 344-354
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400204

T1 - Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats
A1 - Hai-tao Yu
A1 - Juan Zhen
A1 - Bo Pang
A1 - Jin-ning Gu
A1 - Sui-sheng Wu
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 5
SP - 344
EP - 354
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400204

We evaluated the cardioprotective effects of ginsenoside Rg1 in a diabetic rat model induced with high-fat diet and intraperitoneal injection of streptozotocin. ginsenoside Rg1 was injected intraperitoneally for 12 weeks. Myocardial injury indices and oxidative stress markers were determined. Changes in cardiac ultrastructure were evaluated with transmission electron microscopy. Myocardial apoptosis was assessed via terminal deoxynucleotidyl transferase (TDT)-mediated DNA nick-end labeling (TUNEL) and immunohistochemistry. ginsenoside Rg1 was associated with a significant dose-dependent reduction in serum levels of creatinine kinase MB and cardiac troponin I, and lessened ultrastructural disorders in diabetic myocardium, relative to the untreated diabetic model rats. Also, compared with the untreated diabetic rats, significant reductions in serum and myocardial levels of malondialdehyde were noted in the ginsenoside Rg1-treated groups, and increased levels of the antioxidants (superoxide dismutase, catalase, and glutathione peroxidase) were detected. TUNEL staining indicated reduced myocardial apoptosis in ginsenoside Rg1-treated rats, which may be associated with reduced levels of caspase-3 (CASP3) and increased levels of B-cell lymphoma-extra-large (Bcl-xL) in the diabetic myocardium. ginsenoside Rg1 treatment of diabetic rats was associated with reduced oxidative stress and attenuated myocardial apoptosis, suggesting that ginsenoside Rg1 may be of potential preventative and therapeutic value for cardiovascular injury in diabetic patients.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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