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On-line Access: 2024-08-27
Received: 2023-10-17
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Recent advances in lung-on-a-chip technology for modeling respiratory disease
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Jorge A. Tavares-Negrete, Prativa Das, Sahar Najafikhoshnoo, Steven Zanganeh & Rahim Esfandyarpour. Recent advances in lung-on-a-chip technology for modeling respiratory disease[J]. Journal of Zhejiang University Science D, 2023, 6(5): 563–585.
@article{title="Recent advances in lung-on-a-chip technology for modeling respiratory disease",
author="Jorge A. Tavares-Negrete, Prativa Das, Sahar Najafikhoshnoo, Steven Zanganeh & Rahim Esfandyarpour",
journal="Journal of Zhejiang University Science D",
volume="6",
number="5",
pages="563–585",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00241-7"
}
%0 Journal Article
%T Recent advances in lung-on-a-chip technology for modeling respiratory disease
%A Jorge A. Tavares-Negrete
%A Prativa Das
%A Sahar Najafikhoshnoo
%A Steven Zanganeh & Rahim Esfandyarpour
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 5
%P 563–585
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00241-7
TY - JOUR
T1 - Recent advances in lung-on-a-chip technology for modeling respiratory disease
A1 - Jorge A. Tavares-Negrete
A1 - Prativa Das
A1 - Sahar Najafikhoshnoo
A1 - Steven Zanganeh & Rahim Esfandyarpour
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 5
SP - 563–585
EP -
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00241-7
Abstract: Tissue engineering approaches, including those to functional lung tissues, are finely honed by the inclusion of upgraded devices that mimic biophysical and biochemical features in vivo. Perfusion culture is one of these essential biophysical characteristics enabled by the introduction of microfluidic devices in recent years. This review links the importance of dynamic culture for in vitro maintenance of functional lung cells to the modeling of respiratory disease. We identify and discuss different parameters for fabricating the requisite microfluidic models for lung cells, as well as their application in modeling lung diseases caused by external factors such as smoking and pollution. The possibility of creating a multi-organ-on-a-chip to establish a more physiologically relevant model is highlighted. Overall, the focus is on different prospects for the in vitro modeling approach and for lungs-on-a-chip for developing advanced, reliable technology to analyze the pathophysiology of respiratory diseases and screen potential treatments.
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