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Development and characterization of 3D-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering
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Sara De Nitto, Aleksandra Serafin, Alexandra Karadimou, Achim Schmalenberger, John J. E. Mulvihill & Maurice N. Collins. Development and characterization of 3D-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering[J]. Journal of Zhejiang University Science D, 2024, 7(3): 262-276.
@article{title="Development and characterization of 3D-printed electroconductive
pHEMA-co-MAA NP-laden hydrogels for tissue engineering",
author="Sara De Nitto, Aleksandra Serafin, Alexandra Karadimou, Achim Schmalenberger, John J. E. Mulvihill & Maurice N. Collins",
journal="Journal of Zhejiang University Science D",
volume="7",
number="3",
pages="262-276",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00272-8"
}
%0 Journal Article
%T Development and characterization of 3D-printed electroconductive
pHEMA-co-MAA NP-laden hydrogels for tissue engineering
%A Sara De Nitto
%A Aleksandra Serafin
%A Alexandra Karadimou
%A Achim Schmalenberger
%A John J. E. Mulvihill & Maurice N. Collins
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 3
%P 262-276
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00272-8
TY - JOUR
T1 - Development and characterization of 3D-printed electroconductive
pHEMA-co-MAA NP-laden hydrogels for tissue engineering
A1 - Sara De Nitto
A1 - Aleksandra Serafin
A1 - Alexandra Karadimou
A1 - Achim Schmalenberger
A1 - John J. E. Mulvihill & Maurice N. Collins
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 3
SP - 262
EP - 276
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00272-8
Abstract: Tissue engineering (TE) continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue
replacement and tissue regeneration. In this study, we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)
(pHEMA-co-MAA) based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene) (PEDOT)
and polypyrrole (PPy) nanoparticles (NPs), and subsequently processed these hydrogels into tissue engineered constructs
via three-dimensional (3D) printing. The presence of the NPs was critical as they altered the rheological properties during
printing. However, all samples exhibited suitable shear thinning properties, allowing for the development of an optimized
processing window for 3D printing. Samples were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm
in height and diameter, respectively. We observed that the NPs disrupted the gel crosslinking efficiencies, leading to shorter
degradation times and compressive mechanical properties ranging between 450 and 550 kPa. The conductivity of the printed
hydrogels increased along with the NP concentration to (5.10±0.37)×10−7 S/cm. In vitro studies with cortical astrocyte cell
cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular viability and proliferation
rates. Finally, hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels
affected bacterial growth. Taken together, these materials show promise for various TE strategies.
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