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Bio-Design and Manufacturing  2020 Vol.3 No.4 P.373-382

http://doi.org/10.1007/s42242-020-00091-7


Bilayered nanosheets used for complex topography wound anti‑infection


Author(s):  Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi

Affiliation(s):  Peking University Shenzhen Institute, Peking University, Shenzhen, People’s Republic of China; more

Corresponding email(s):   shxt@scut.edu.cn

Key Words:  Nanosheet, Adhesive, Complicated topography, Antimicrobial


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Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi . Bilayered nanosheets used for complex topography wound anti‑infection[J]. Journal of Zhejiang University Science D, 2020, 3(4): 373-382.

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Abstract: 
There is a consensus that the prevention of wound infection should be achieved in the following ways: (1) closing the wound to protect it from extra infection; (2) an antibacterial agent that could kill endogenous bacteria. However, existing bulk two-dimensional antibacterial materials show inefcient adhesion to wounds with complex morphology and thus cause the prevention of wound closure. Reducing the thickness of bulk two-dimensional materials to less than 100 nanometres endows them with great fexibility, which could allow them to adhere to wounds with complex morphology by only physical adhesion. Herein, a broad-spectrum and efcient antimicrobial peptide (AMP) was introduced to biocompatible methacrylated gelatine (GelMA) with multiple modifcation sites, which served as an inner antibacterial layer. After being combined with a biodegradable and good mechanical poly-l-lactide (PLLA) outer layer through plasma-treatment-assisted spin coating, we fnally constructed bilayered antibacterial nanosheets with a thickness of approximately 80 nm. These bilayered nanosheets possess good adhesion to surfaces with complex topography and thus achieve better wound closure than other bulk two-dimensional materials. Moreover, this AMP-grafted conjugation shows minimal cytotoxicity compared with Ag+ antibacterial agents, and the antibacterial rate of nanosheets is dependent on the graft rate of AMP. We suggest that this bilayered antibacterial nanosheet might be an advanced anti-infection dressing for wound treatment in clinical settings.

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