Full Text:   <1442>

CLC number: 

On-line Access: 2020-08-20

Received: 2020-05-26

Revision Accepted: 2020-08-01

Crosschecked: 2020-08-29

Cited: 0

Clicked: 1435

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2020 Vol.3 No.4 P.373-382

http://doi.org/10.1007/s42242-020-00091-7


Bilayered nanosheets used for complex topography wound anti?infection


Author(s):  Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi

Affiliation(s):  Peking University Shenzhen Institute, Peking University, Shenzhen, Peoples Republic of China; more

Corresponding email(s):   shxt@scut.edu.cn

Key Words:  Nanosheet, Adhesive, Complicated topography, Antimicrobial


Share this article to: More

Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi . Bilayered nanosheets used for complex topography wound anti?infection[J]. Journal of Zhejiang University Science D, 2020, 3(4): 373-382.

@article{title="Bilayered nanosheets used for complex topography wound anti?infection",
author="Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi ",
journal="Journal of Zhejiang University Science D",
volume="3",
number="4",
pages="373-382",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00091-7"
}

%0 Journal Article
%T Bilayered nanosheets used for complex topography wound anti?infection
%A Chengkai Xuan
%A Xuemin Liu
%A Chen Lai & Xuetao Shi
%J Journal of Zhejiang University SCIENCE D
%V 3
%N 4
%P 373-382
%@ 1869-1951
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00091-7

TY - JOUR
T1 - Bilayered nanosheets used for complex topography wound anti?infection
A1 - Chengkai Xuan
A1 - Xuemin Liu
A1 - Chen Lai & Xuetao Shi
J0 - Journal of Zhejiang University Science D
VL - 3
IS - 4
SP - 373
EP - 382
%@ 1869-1951
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-020-00091-7


Abstract: 
There is a consensus that the prevention of wound infection should be achieved in the following ways: (1) closing the wound to protect it from extra infection; (2) an antibacterial agent that could kill endogenous bacteria. However, existing bulk two-dimensional antibacterial materials show inefcient adhesion to wounds with complex morphology and thus cause the prevention of wound closure. Reducing the thickness of bulk two-dimensional materials to less than 100 nanometres endows them with great fexibility, which could allow them to adhere to wounds with complex morphology by only physical adhesion. Herein, a broad-spectrum and efcient antimicrobial peptide (AMP) was introduced to biocompatible methacrylated gelatine (GelMA) with multiple modifcation sites, which served as an inner antibacterial layer. After being combined with a biodegradable and good mechanical poly-l-lactide (PLLA) outer layer through plasma-treatment-assisted spin coating, we fnally constructed bilayered antibacterial nanosheets with a thickness of approximately 80 nm. These bilayered nanosheets possess good adhesion to surfaces with complex topography and thus achieve better wound closure than other bulk two-dimensional materials. Moreover, this AMP-grafted conjugation shows minimal cytotoxicity compared with Ag+ antibacterial agents, and the antibacterial rate of nanosheets is dependent on the graft rate of AMP. We suggest that this bilayered antibacterial nanosheet might be an advanced anti-infection dressing for wound treatment in clinical settings.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE