CLC number:
On-line Access: 2020-08-20
Received: 2020-05-26
Revision Accepted: 2020-08-01
Crosschecked: 2020-08-29
Cited: 0
Clicked: 1559
Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi . Bilayered nanosheets used for complex topography wound anti?infection[J]. Journal of Zhejiang University Science D, 2020, 3(4): 373-382.
@article{title="Bilayered nanosheets used for complex topography wound
anti?infection",
author="Chengkai Xuan, Xuemin Liu, Chen Lai & Xuetao Shi ",
journal="Journal of Zhejiang University Science D",
volume="3",
number="4",
pages="373-382",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00091-7"
}
%0 Journal Article
%T Bilayered nanosheets used for complex topography wound
anti?infection
%A Chengkai Xuan
%A Xuemin Liu
%A Chen Lai & Xuetao Shi
%J Journal of Zhejiang University SCIENCE D
%V 3
%N 4
%P 373-382
%@ 1869-1951
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00091-7
TY - JOUR
T1 - Bilayered nanosheets used for complex topography wound
anti?infection
A1 - Chengkai Xuan
A1 - Xuemin Liu
A1 - Chen Lai & Xuetao Shi
J0 - Journal of Zhejiang University Science D
VL - 3
IS - 4
SP - 373
EP - 382
%@ 1869-1951
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-020-00091-7
Abstract: There is a consensus that the prevention of wound infection should be achieved in the following ways: (1) closing the wound
to protect it from extra infection; (2) an antibacterial agent that could kill endogenous bacteria. However, existing bulk
two-dimensional antibacterial materials show inefcient adhesion to wounds with complex morphology and thus cause the
prevention of wound closure. Reducing the thickness of bulk two-dimensional materials to less than 100 nanometres endows
them with great fexibility, which could allow them to adhere to wounds with complex morphology by only physical adhesion.
Herein, a broad-spectrum and efcient antimicrobial peptide (AMP) was introduced to biocompatible methacrylated gelatine
(GelMA) with multiple modifcation sites, which served as an inner antibacterial layer. After being combined with a biodegradable and good mechanical poly-l-lactide (PLLA) outer layer through plasma-treatment-assisted spin coating, we fnally
constructed bilayered antibacterial nanosheets with a thickness of approximately 80 nm. These bilayered nanosheets possess
good adhesion to surfaces with complex topography and thus achieve better wound closure than other bulk two-dimensional
materials. Moreover, this AMP-grafted conjugation shows minimal cytotoxicity compared with Ag+ antibacterial agents,
and the antibacterial rate of nanosheets is dependent on the graft rate of AMP. We suggest that this bilayered antibacterial
nanosheet might be an advanced anti-infection dressing for wound treatment in clinical settings.
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