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Bio-Design and Manufacturing  2020 Vol.3 No.4 P.281-306

http://doi.org/10.1007/s42242-020-00094-4


The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques


Author(s):  Ashkan Bigham, Firoozeh Foroughi, Erfan Rezvani Ghomi, Mohammad Rafenia, Rasoul Esmaeely Neisiany, Seeram Ramakrishna

Affiliation(s):  Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine (ATiM), Isfahan University of Medical Sciences, Isfahan, Iran; more

Corresponding email(s):   m_rafenia@med.mui.ac.ir, seeram@nus.edu.sg

Key Words:  Multifunctional scafolds, Bone cancer, Fabrication techniques, Bone tissue regeneration


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Ashkan Bigham, Firoozeh Foroughi, Erfan Rezvani Ghomi, Mohammad Rafenia, Rasoul Esmaeely Neisiany, Seeram Ramakrishna. The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques[J]. Journal of Zhejiang University Science D, 2020, 3(4): 281-306.

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author="Ashkan Bigham, Firoozeh Foroughi, Erfan Rezvani Ghomi, Mohammad Rafenia, Rasoul Esmaeely Neisiany, Seeram Ramakrishna",
journal="Journal of Zhejiang University Science D",
volume="3",
number="4",
pages="281-306",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00094-4"
}

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%J Journal of Zhejiang University SCIENCE D
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%I Zhejiang University Press & Springer
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A1 - Seeram Ramakrishna
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Abstract: 
As a bone scafold, meeting all basic requirements besides dealing with other bone-related issuesbone cancer and accelerated regenerationis not expected from traditional scafolds, but a newer class of scafolds called multifunctional. From a clinical point of view, being a multifunctional scafold means reducing in healing time, direct costsmedicine, surgery, and hospitalizationand indirect costsloss of mobility, losing job, and pain. The main aim of the present review is following the multifunctional bone scafolds trend to deal with both bone regeneration and cancer therapy. Special consideration is given to diferent fabrication techniques which have been applied to yield these materials spanning from traditional to modern ones. Moreover, the hierarchical structure of bone plus bone cancers and available medicines to them are introduced to familiarize the potential reader of review with the pluri-disciplinary essence of the feld. Eventually, a brief discussion relating to the future trend of these materials is provided.

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