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Bio-Design and Manufacturing  2022 Vol.5 No.1 P.85-106

http://doi.org/10.1007/s42242-021-00157-0


From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery systems and personalized medicine


Author(s):  Niels G. A. Willemen, Margaretha A. J. Morsink, Devin Veerman, Classius F. da Silva, Juliana C. Cardoso, Eliana B. Souto & Patrícia Severino

Affiliation(s):  Niels G. A. Willemen, Margaretha A. J. Morsink, and Devin Veerman have contributed equally to this work; more

Corresponding email(s):   ebsouto@ff.uc.pt, patricia_severino@itp.org.br

Key Words:  Drug delivery systems 3D/4D printing, Drug-eluting implants, Microneedles, Oral formulations


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Niels G. A. Willemen, Margaretha A. J. Morsink, Devin Veerman, Classius F. da Silva, Juliana C. Cardoso, Eliana B. Souto & Patrícia Severino. From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery systems and personalized medicine[J]. Journal of Zhejiang University Science D, 2022, 5(1): 85-106.

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Abstract: 
Since the start of the Precision Medicine Initiative by the United States of America in 2015, interest in personalized medicine has grown extensively. In short, personalized medicine is a term that describes medical treatment that is tuned to the individual. One possible way to realize personalized medicine is 3D printing. When using materials that can be tuned upon stimulation, 4D printing is established. In recent years, many studies have been exploring a new field that combines 3D and 4D printing with therapeutics. This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and, possibly, tailored to an individual. Moreover, the first 3D printed drug, Spritam®, has already found its way to the clinic. This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

哈佛医学院Patrícia Severino等 | 从口服制剂到药物洗脱植入物:使用3D和4D打印开发药物输送系统和个性化医疗

本综述论文聚焦3D和4D打印在药物递送和精准医疗上的应用。自2015年美国启动精准医疗倡议以来,人们对个性化医疗的兴趣广泛增长。简言之,个性化医疗是一个针对个人医疗的术语。实现个性化医疗的一种可能方法是3D打印。当使用可以在受到刺激时可进行调控的材料进行3D打印时,就产生了4D打印的概念。近年来,许多研究人员一直在探索一个将3D和4D打印与治疗相结合的新领域。这产生了许多制药设备和配方的概念,且可能为个人量身定制。此外,第一种3D打印药物Spritam®已经进入临床阶段。本文综述了各种3D和4D打印技术及其在制药领域作为药物输送系统和个性化医疗的应用。

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