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Bio-Design and Manufacturing  2023 Vol.6 No.1 P.51-73

http://doi.org/10.1007/s42242-022-00212-4


Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis


Author(s):  Weiying Lu, Yang Shi & Zhijian Xie

Affiliation(s):  Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   xzj66@zju.edu.cn

Key Words:  3D printing, Angiogenesis, Bone regeneration, Tissue engineering, Biomimetic scaffolds


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Weiying Lu, Yang Shi & Zhijian Xie. Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis[J]. Journal of Zhejiang University Science D, 2023, 6(1): 51-73.

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Abstract: 
Large bone defect regeneration has always been recognized as a challenging clinical problem due to the difficulty of revascularization. Conventional treatments exhibit certain inherent disadvantages (e.g., secondary injury, immunization, and potential infections). However, three-dimensional (3D) printing technology as an emerging field can serve as an effective approach to achieve satisfactory revascularization while making up for the above limitations. A wide variety of methods can be used to facilitate blood supply during the design of a 3D-printed scaffold. Importantly, the scaffold structure lays a foundation for the entire printing object; any method to promote angiogenesis can be effective only if it is based on well-designed scaffolds. In this review, different designs related to angiogenesis are summarized by collecting the literature from recent years. The 3D-printed scaffolds are classified into four major categories and discussed in detail, from elementary porous scaffolds to the most advanced bone-like scaffolds. Finally, structural design suggestions to achieve rapid angiogenesis are proposed by analyzing the above architectures. This review can provide a reference for organizations or individual academics to achieve improved bone defect repair and regeneration using 3D printing.

浙江大学谢志坚等 | 促进3D打印成骨移植物内血管快速生成的创新结构设计

本综述论文聚焦于3D生物打印促进骨再生中的结构和血运重建之间的关系。由于血运重建的困难,大段骨缺损的再生一直被认为是一个具有挑战性的临床问题。同时骨缺损在临床的常规治疗中存在着一些缺点,例如二次伤害、免疫和潜在感染。然而,3D打印技术可以作为一种有效的方法来实现令人满意的血管再生,同时弥补上述局限性。在3D打印支架的设计过程中,可以使用多种方法来促进血液供应。重要的是,支架结构为整个印刷物体奠定了基础;任何促进血管生成的方法只有基于精心设计的支架才能有效。本文通过收集近年来的文献,总结了与血管生成相关的不同设计,并将其分为四大类进行详细讨论,从基本的多孔支架到最先进的类骨支架。最后,通过对上述结构的分析,提出了实现快速血管生成的结构设计建议,希望能为未来3D打印实现骨缺损修复和再生提供参考。

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