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On-line Access: 2025-09-19
Received: 2025-01-13
Revision Accepted: 2025-05-08
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Nuclear-targeted reactive oxygen species burst: a self-amplifying nanoplatform that overcomes hypoxia and redox barriers for enhanced sonodynamic cancer therapy
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Xiaoyuan Wang (王晓圆), Meng Li (李梦), Rong Cheng (成荣), Liting Zhao (赵立亭), Yanfeng Xi (郗彦凤), Jianming Wang (王建明), Peng Gao (高鹏), Lingqian Chang (常凌乾), Zixian Liu (刘姿娴), Di Huang (黄棣) & Shengbo Sang (桑胜波). Nuclear-targeted reactive oxygen species burst: a self-amplifying nanoplatform that overcomes hypoxia and redox barriers for enhanced sonodynamic cancer therapy[J]. Journal of Zhejiang University Science D, 2025, 8(5): 776-799.
@article{title=" Nuclear-targeted reactive oxygen species burst: a self-amplifying
nanoplatform that overcomes hypoxia and redox barriers for enhanced
sonodynamic cancer therapy",
author="Xiaoyuan Wang (王晓圆), Meng Li (李梦), Rong Cheng (成荣), Liting Zhao (赵立亭), Yanfeng Xi (郗彦凤), Jianming Wang (王建明), Peng Gao (高鹏), Lingqian Chang (常凌乾), Zixian Liu (刘姿娴), Di Huang (黄棣) & Shengbo Sang (桑胜波)",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="776-799",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500021"
}
%0 Journal Article
%T Nuclear-targeted reactive oxygen species burst: a self-amplifying
nanoplatform that overcomes hypoxia and redox barriers for enhanced
sonodynamic cancer therapy
%A Xiaoyuan Wang (王晓圆)
%A Meng Li (李梦)
%A Rong Cheng (成荣)
%A Liting Zhao (赵立亭)
%A Yanfeng Xi (郗彦凤)
%A Jianming Wang (王建明)
%A Peng Gao (高鹏)
%A Lingqian Chang (常凌乾)
%A Zixian Liu (刘姿娴)
%A Di Huang (黄棣) & Shengbo Sang (桑胜波)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 776-799
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500021
TY - JOUR
T1 - Nuclear-targeted reactive oxygen species burst: a self-amplifying
nanoplatform that overcomes hypoxia and redox barriers for enhanced
sonodynamic cancer therapy
A1 - Xiaoyuan Wang (王晓圆)
A1 - Meng Li (李梦)
A1 - Rong Cheng (成荣)
A1 - Liting Zhao (赵立亭)
A1 - Yanfeng Xi (郗彦凤)
A1 - Jianming Wang (王建明)
A1 - Peng Gao (高鹏)
A1 - Lingqian Chang (常凌乾)
A1 - Zixian Liu (刘姿娴)
A1 - Di Huang (黄棣) & Shengbo Sang (桑胜波)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 776
EP - 799
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500021
Abstract: Although sonodynamic therapy (SDT) is a promising cancer treatment that induces DNA and macromolecular damage
through the generation of reactive oxygen species (ROS), its therapeutic efficacy is limited by local hypoxia and ROS de
fense mechanisms in tumors. This study proposed a novel tumor treatment approach, focusing on ROS-mediated therapy by
targeting the nucleus and depleting glutathione (GSH) levels, which was achieved through a nanoplatform (Pt2+-CDs@PpIX)
with integrated functions including GSH detection and depletion, pH-responsive drug release, and nuclear targeting. The
Pt2+-CDs@PpIX nanoplatform effectively differentiated normal and cancer cells and also exhibited excellent biocompatibil
ity. Depletion of GSH levels and increased ROS sensitivity of cells significantly improved the effectiveness of SDT, as dem
onstrated in vitro using Pt2+-CDs@PpIX, which also exhibited significant cellular uptake. Pt2+-CDs@PpIX exerted potent
antitumor effects in both two-dimensional and three-dimensional tumor microenvironment models (3DM-7721). Moreover,
in 3DM-7721 models, hepatoma cells (SMMC-7721) demonstrated significant inhibition of motility, invasion, and colony
formation after exposure to Pt2+-CDs@PpIX. Furthermore, intravenous administration of the Pt2+-CDs@PpIX nanoplatform
enabled precise and rapid tumor-targeting, followed by ultrasound-triggered therapy, without adverse effects in nude mice.
Hence, this nanoplatform provides a promising strategy for designing cancer therapies and delivering nuclear-targeted drugs.
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