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Bio-Design and Manufacturing  2025 Vol.8 No.5 P.909-916

http://doi.org/10.1631/bdm.2500186


Automated device for small-tissue extraction and primary organoid modeling


Author(s):  Wanlong Wang (王皖龙), Yongde Cai (蔡咏德), Davit Khutsishvili, Xiaoyong Dai (代小勇), Yifu Wei (韦一福), Zhiyuan Liu (刘志远), Yu Zhu (朱雨), Zitian Wang (王子天) & Shaohua Ma (马少华)

Affiliation(s):  nstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen 518055, China; more

Corresponding email(s):   ma.shaohua@sz.tsinghua.edu.cn

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Wanlong Wang (王皖龙), Yongde Cai (蔡咏德), Davit Khutsishvili, Xiaoyong Dai (代小勇), Yifu Wei (韦一福), Zhiyuan Liu (刘志远), Yu Zhu (朱雨), Zitian Wang (王子天) & Shaohua Ma (马少华) . Automated device for small-tissue extraction and primary organoid modeling[J]. Journal of Zhejiang University Science D, 2025, 8(5): 909-916.

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Abstract: 
从原代样本中提取的细胞对于构建患者同源类器官模型至关重要。 然而, 目前的自动化细胞提取设备存在诸多不足: 一方面, 它们主要用于处理手术切除的组织; 另一方面, 它们操作流程繁琐耗时, 单次处理需要约半小时, 极大地限制了从少量活检样本中提取细胞的效率。 为了解决这些问题, 我们开发了一种小型组织细胞提取装置 (small-tissue extraction device, sTED), 该装置采用研磨方式提取细胞。 其核心部件为微型三棱锥和三棱柱形成的一套微型刀片阵列, 它可以在提取细胞的同时保障细胞完整性; 在运行 1 分钟的时间内, 其内部刀片阵列可完成 150 万次微剪切操作。 此外, 我们设计了研磨消化一体的研磨室, 使其能够高效地处理多种尺寸的组织样本 (从小型穿刺活检样本到大型手术切除样本)。 在小鼠肝脏和肺组织细胞提取的实验中, sTED 提取的细胞活率均超过了 90%。 sTED 是首批能在不降低细胞得率和活率的前提下, 可靠地处理超小组织样本的设备之一, 其效果超过了熟练的人工操作。 这一创新成果解决了穿刺取样细胞量不足与自动化设备高细胞需求量之间的矛盾, 为类器官技术的临床转化提供支持。

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