JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.6 P.429-435

http://doi.org/10.1631/jzus.2006.B0429

Guava extract (Psidium guajava) alters the labelling of blood constituents with technetium-99m

Author(s): ABREU P.R.C., ALMEIDA M.C., BERNARDO R.M., BERNARDO L.C., BRITO L.C., GARCIA E.A.C., FONSECA A.S., BERNARDO-FILHO M.
Affiliation(s): Department of Biophysics and Biometry, Institute of Biology Roberto Alcantara Gomes, University of Estate of Rio de Janeiro, Rio de Janeiro 20551030, Brazil; more
Corresponding email(s): adenilso@uerj.br
Key Words: Antioxidant, Blood constituents, Psidium guajava, Technetium-99m

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Abstract: Psidium guajava (guava) leaf is a phytotherapic used in folk medicine to treat gastrointestinal and respiratory disturbances and is used as anti-inflammatory medicine. In nuclear medicine, blood constituents (BC) are labelled with technetium-99m (^99mTc) and used to image procedures. However, data have demonstrated that synthetic or natural drugs could modify the labelling of BC with ^99mTc. The aim of this work was to evaluate the effects of aqueous extract of guava leaves on the labelling of BC with ^99mTc. Blood samples of Wistar rats were incubated with different concentrations of guava extract and labelled with ^99mTc after the percentage of incorporated radioactivity (%ATI) in BC was determined. The results suggest that aqueous guava extract could present antioxidant action and/or alters the membrane structures involved in ion transport into cells, thus decreasing the radiolabelling of BC with ^99mTc. The data showed significant (P<0.05) alteration of ATI in BC from blood incubated with guava extract.

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