HER-2 overexpression and survival in colorectal cancer: a meta-analysis
| ||||||||||||||
Chao Li, Da-ren Liu, Long-yun Ye, Ling-na Huang, Sanjay Jaiswal, Xiao-wen Li, Hou-hong Wang, Li Chen. HER-2 overexpression and survival in colorectal cancer: a meta-analysis[J]. Journal of Zhejiang University Science B, 2014, 15(6): 582-589.
@article{title="HER-2 overexpression and survival in colorectal cancer: a meta-analysis",
author="Chao Li, Da-ren Liu, Long-yun Ye, Ling-na Huang, Sanjay Jaiswal, Xiao-wen Li, Hou-hong Wang, Li Chen",
journal="Journal of Zhejiang University Science B",
volume="15",
number="6",
pages="582-589",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300258"
}
%0 Journal Article
%T HER-2 overexpression and survival in colorectal cancer: a meta-analysis
%A Chao Li
%A Da-ren Liu
%A Long-yun Ye
%A Ling-na Huang
%A Sanjay Jaiswal
%A Xiao-wen Li
%A Hou-hong Wang
%A Li Chen
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 6
%P 582-589
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300258
TY - JOUR
T1 - HER-2 overexpression and survival in colorectal cancer: a meta-analysis
A1 - Chao Li
A1 - Da-ren Liu
A1 - Long-yun Ye
A1 - Ling-na Huang
A1 - Sanjay Jaiswal
A1 - Xiao-wen Li
A1 - Hou-hong Wang
A1 - Li Chen
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 6
SP - 582
EP - 589
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300258
Abstract: Objective: Numerous studies examining the relationship between human epidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value. Methods: Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival. Results: Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77–1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50–1.29; HR=0.90, 95% CI: 0.43–1.37, respectively). Conclusions: Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival.
Full Text:
<4921>
CLC number: R735.3
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2014-05-25
Cited: 3
Clicked: 11686
Open peer comments: Debate/Discuss/Question/Opinion
<1>