CLC number: R605.971
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2016-12-16
Cited: 0
Clicked: 4282
Jiu-kun Jiang, Wen Fang, Liang-jie Hong, Yuan-qiang Lu. Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock[J]. Journal of Zhejiang University Science B, 2017, 18(1): 48-58.
@article{title="Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock",
author="Jiu-kun Jiang, Wen Fang, Liang-jie Hong, Yuan-qiang Lu",
journal="Journal of Zhejiang University Science B",
volume="18",
number="1",
pages="48-58",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600510"
}
%0 Journal Article
%T Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock
%A Jiu-kun Jiang
%A Wen Fang
%A Liang-jie Hong
%A Yuan-qiang Lu
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 1
%P 48-58
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600510
TY - JOUR
T1 - Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock
A1 - Jiu-kun Jiang
A1 - Wen Fang
A1 - Liang-jie Hong
A1 - Yuan-qiang Lu
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 1
SP - 48
EP - 58
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600510
Abstract: Objective: To investigate the distribution and differentiation of myeloid-derived suppressor cells (MDSCs) in hemorrhagic shock mice, which are resuscitated with normal saline (NS), hypertonic saline (HTS), and hydroxyethyl starch (HES). Methods: BALB/c mice were randomly divided into control, NS, HTS, and HES resuscitation groups. Three subgroups (n=8) in each resuscitation group were marked as 2, 24, and 72 h. Flow cytometry was used to detect the MDSCs, monocytic MDSCs (M-MDSCs), and granulocytic/neutrophilic MDSCs (G-MDSCs) in peripheral blood nucleated cells (PBNCs), spleen single-cell suspension, and bone marrow nucleated cells (BMNCs). Results: The MDSCs in BMNCs among three resuscitation groups were lower 2 h after shock, in PBNCs of the HTS group were higher, and in spleen of the NS group were lower (all P<0.05 vs. control). The M-MDSC/G-MDSC ratios in PBNCs of the HTS and HES groups were lower (both P<0.05 vs. control). At 24 h, the MDSCs in PBNCs of the NS and HTS groups were higher, while the spleen MDSCs in the HTS group were higher (all P<0.05 vs. control). The M-MDSC/ G-MDSC ratios were all less in PBNCs, spleen, and BMNCs of the NS and HTS groups, and were lower in BMNCs of the HES group (all P<0.05 vs. control). At 72 h, the elevated MDSCs in PBNCs were presented in the HTS and HES groups, and in spleen the augment turned up in three resuscitation groups (all P<0.05 vs. control). The inclined ratios to M-MDSC were exhibited in spleen of the NS and HTS groups, and in PBNCs of the NS group; the inclination to G-MDSC in BMNCs was shown in the HES group (all P<0.05 vs. control). Conclusions: HTS induces the earlier elevation of MDSCs in peripheral blood and spleen, and influences its distribution and differentiation, while HES has a less effect on the distribution but a stronger impact on the differentiation of MDSCs, especially in bone marrow.
[1]Anna, B., Massimo, C., Simone, G., et al., 2016. Pilot randomized controlled trial evaluating the effect of hypertonic saline with and without hyaluronic acid in reducing inflammation in cystic fibrosis. J. Aerosol. Med. Pulm. Drug Deliv., 29(6):482-489.
[2]Arun, S., Burawat, J., Sukhorum, W., et al., 2016. Changes of testicular phosphorylated proteins in response to restraint stress in male rats. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 17(1):21-29.
[3]Brudecki, L., Ferguson, D.A., McCall, C.E., et al., 2012. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect. Immun., 80(6):2026-2034.
[4]Bulger, E.M., Jurkovich, G.J., Nathens, A.B., et al., 2008. Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch. Surg., 143(2):139-148, discussion 149.
[5]Bulger, E.M., May, S., Kerby, J.D., et al., 2011. Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial. Ann. Surg., 253(3):431-441.
[6]Chang, M., Tang, H., Liu, D., et al., 2016. Comparison of melatonin, hypertonic saline, and hydroxyethyl starch for resuscitation of secondary intra-abdominal hypertension in an animal model. PLoS ONE, 11(8):e0161688.
[7]Chen, G., You, G., Wang, Y., et al., 2013. Effects of synthetic colloids on oxidative stress and inflammatory response in hemorrhagic shock: comparison of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin. Crit. Care, 17(4):R141.
[8]Chen, L.W., Su, M.T., Chen, P.H., et al., 2011. Hypertonic saline enhances host defense and reduces apoptosis in burn mice by increasing Toll-like receptors. Shock, 35(1):59-66.
[9]Choi, S.H., Yoon, Y.H., Kim, J.Y., et al., 2014. The effect of hypertonic saline on mRNA of proinflammatory cytokines in lipopolysaccharide-stimulated polymorphonuclear cells. Curr. Ther. Res., 76:58-62.
[10]Coimbra, R., Junger, W.G., Hoyt, D.B., et al., 1996. Hypertonic saline resuscitation restores hemorrhage-induced immunosuppression by decreasing prostaglandin E2 and interleukin-4 production. J. Surg. Res., 64(2):203-209.
[11]Cuenca, A.G., Delano, M.J., Kelly-Scumpia, K.M., et al., 2011. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol. Med., 17(3-4):281-292.
[12]Delano, M.J., Scumpia, P.O., Weinstein, J.S., et al., 2007. MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis. J. Exp. Med., 204(6):1463-1474.
[13]Dong, F., Chen, W., Xu, L., et al., 2014. Therapeutic effects of compound hypertonic saline on rats with sepsis. Braz. J. Infect. Dis., 18(5):518-525.
[14]Duan, C., Li, T., Liu, L., 2015. Efficacy of limited fluid resuscitation in patients with hemorrhagic shock: a meta-analysis. Int. J. Clin. Exp. Med., 8(7):11645-11656.
[15]Dufait, I., Schwarze, J.K., Liechtenstein, T., et al., 2015. Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer. Oncotarget, 6(14):12369-12382.
[16]Esnault, P., Prunet, B., Cotte, J., et al., 2013. Hydroxyethyl starch 130/0.4 or hypertonic saline solution to decrease inflammatory response in hemorrhagic shock? Crit. Care, 17(5):457.
[17]Gamboni, F., Anderson, C., Sanchayita, M., et al., 2016. Hypertonic saline primes activation of the p53‒p21 signaling axis in human small airway epithelial cells that prevents inflammation induced by pro-inflammatory cytokines. J. Proteome Res., 15(10):3813-3826.
[18]Heim, C.E., Vidlak, D., Scherr, T.D., et al., 2014. Myeloid-derived suppressor cells contribute to Staphylococcus aureus orthopedic biofilm infection. J. Immunol., 192(8):3778-3792.
[19]Huang, H., Liu, J., Hao, H., et al., 2016. G-CSF administration after the intraosseous infusion of hypertonic hydroxyethyl starches accelerating wound healing combined with hemorrhagic shock. BioMed Res. Int., 2016:5317630.
[20]Huang, L.Q., Zhu, G.F., Deng, Y.Y., et al., 2014. Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. J. Neuroinflammation, 11:102.
[21]Huber-Lang, M., Gebhard, F., Schmidt, C.Q., et al., 2016. Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation—closing Pandora’s box? Semin. Immunol., 28(3):278-284.
[22]Igarashi, T., Fujimoto, C., Suzuki, H., et al., 2014. Short-time exposure of hyperosmolarity triggers interleukin-6 expression in corneal epithelial cells. Cornea, 33(12):1342-1347.
[23]Janols, H., Bergenfelz, C., Allaoui, R., et al., 2014. A high frequency of MDSCs in sepsis patients, with the granulocytic subtype dominating in gram-positive cases. J. Leukoc. Biol., 96(5):685-693.
[24]Junger, W.G., Rhind, S.G., Rizoli, S.B., et al., 2012. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline—without dextran—inhibits neutrophil and endothelial cell activation. Shock, 38(4):341-350.
[25]Ke, Q.H., Zheng, S.S., Liang, T.B., et al., 2006. Pretreatment of hypertonic saline can increase endogenous interleukin 10 release to attenuate hepatic ischemia reperfusion injury. Dig. Dis. Sci., 51(12):2257-2263.
[26]Lai, D., Qin, C., Shu, Q., 2014. Myeloid-derived suppressor cells in sepsis. BioMed Res. Int., 2014:598654.
[27]Liu, H., Xiao, X., Sun, C., et al., 2015. Systemic inflammation and multiple organ injury in traumatic hemorrhagic shock. Front. Biosci., 20:927-933.
[28]Liu, Z., Li, Y., Liu, B., et al., 2013. Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model. J. Trauma Acute Care Surg., 74(4):991-998.
[29]Loomis, W.H., Namiki, S., Hoyt, D.B., et al., 2001. Hypertonicity rescues T cells from suppression by trauma-induced anti-inflammatory mediators. Am. J. Physiol. Cell Physiol., 281(3):C840-C848.
[30]Lu, Y.Q., Huang, W.D., Cai, X.J., et al., 2008. Hypertonic saline resuscitation reduces apoptosis of intestinal mucosa in a rat model of hemorrhagic shock. J. Zhejiang Univ.-Sci. B, 9(11):879-884.
[31]Lu, Y.Q., Gu, L.H., Huang, W.D., et al., 2010. Effect of hypertonic saline resuscitation on heme oxygenase-1 mRNA expression and apoptosis of the intestinal mucosa in a rat model of hemorrhagic shock. Chin. Med. J. (Engl.), 123(11):1453-1458.
[32]Lu, Y.Q., Gu, L.H., Zhang, Q., et al., 2013. Hypertonic saline resuscitation contributes to early accumulation of circulating myeloid-derived suppressor cells in a rat model of hemorrhagic shock. Chin. Med. J. (Engl.), 126(7):1317-1322.
[33]Makarenkova, V.P., Bansal, V., Matta, B.M., et al., 2006. CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J. Immunol., 176(4):2085-2094.
[34]Motaharinia, J., Etezadi, F., Moghaddas, A., et al., 2015. Immunomodulatory effect of hypertonic saline in hemorrhagic shock. DARU J. Pharm. Sci., 23:47.
[35]Nagaraj, S., Youn, J.I., Gabrilovich, D.I., 2013. Reciprocal relationship between myeloid-derived suppressor cells and T cells. J. Immunol., 191(1):17-23.
[36]Naumann, D.N., Beaven, A., Dretzke, J., et al., 2016. Searching for the optimal fluid to restore microcirculatory flow dynamics after haemorrhagic shock: a systematic review of preclinical studies. Shock, 46(6):609-622.
[37]O'Connor, M.A., Fu, W.W., Green, K.A., et al., 2015. Subpopulations of M-MDSCs from mice infected by an immunodeficiency-causing retrovirus and their differential suppression of T- vs B-cell responses. Virology, 485:263-273.
[38]Ost, M., Singh, A., Peschel, A., et al., 2016. Myeloid-derived suppressor cells in bacterial infections. Front. Cell Infect. Microbiol., 6:37.
[39]Öztürk, T., Onur, E., Cerrahoğlu, M., et al., 2015. Immune and inflammatory role of hydroxyethyl starch 130/0.4 and fluid gelatin in patients undergoing coronary surgery. Cytokine, 74(1):69-75.
[40]Wang, P., Li, Y., Li, J., 2009. Protective roles of hydroxyethyl starch 130/0.4 in intestinal inflammatory response and oxidative stress after hemorrhagic shock and resuscitation in rats. Inflammation, 32(2):71-82.
[41]Watters, J.M., Tieu, B.H., Todd, S.R., et al., 2006. Fluid resuscitation increases inflammatory gene transcription after traumatic injury. J. Trauma, 61(2):300-309.
[42]Wright, F.L., Gamboni, F., Moore, E.E., et al., 2014. Hyperosmolarity invokes distinct anti-inflammatory mechanisms in pulmonary epithelial cells: evidence from signaling and transcription layers. PLoS ONE, 9(12):e114129.
[43]Youn, J.I., Nagaraj, S., Collazo, M., et al., 2008. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J. Immunol., 181(8):5791-5802.
[44]Youn, J.I., Kumar, V., Collazo, M., et al., 2013. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat. Immunol., 14(3):211-220.
[45]Zhang, Q., Lu, Y.Q., Jiang, J.K., et al., 2012. Early changes of CD4+CD25+Foxp3+ regulatory T cells and Th1/Th2, Tc1/Tc2 profiles in the peripheral blood of rats with controlled hemorrhagic shock and no fluid resuscitation. Chin. Med. J. (Engl.), 125(12):2163-2167.
[46]Zhou, J., Donatelli, S.S., Gilvary, D.L., et al., 2016. Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin. Sci. Rep., 6:29521.
[47]Zoglmeier, C., Bauer, H., Nörenberg, D., et al., 2011. CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice. Clin. Cancer Res., 17(7):1765-1775.
Open peer comments: Debate/Discuss/Question/Opinion
<1>