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Abstract: Objective: The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up. Methods: This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance. Results: One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30‒8.58). Conclusions: The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.

中国肥胖儿童青少年多巴胺受体D2基因多态性与随访8年后体重变化的相关性研究

[1]1000 Genomes Project Consortium, Auton A, Brooks LD, et al., 2015. A global reference for human genetic variation. Nature, 526(7571):68-74.

[2]Bray GA, Heisel WE, Afshin A, et al., 2018. The science of obesity management: an endocrine society scientific statement. Endocr Rev, 39(2):79-132.

[3]Carpenter CL, Wong AM, Li ZP, et al., 2013. Association of dopamine D₂ receptor and leptin receptor genes with clinically severe obesity. Obesity (Silver Spring), 21(9):E467-E473.

[4]Collaboration NRF, 2017. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128∙9 million children, adolescents, and adults. Lancet, 390(10113):2627-2642.

[5]de Onis M, Onyango AW, Borghi E, et al., 2007. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ, 85(9):660-667.

[6]Garcia-Tornadú I, Perez-Millan MI, Recouvreux V, et al., 2010. New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2^–/– mouse. Neuroendocrinology, 92(4):207-214.

[7]Gosso MF, de Geus EJ, Polderman TJ, et al., 2008. Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and gene-gene interaction on working memory functioning. Eur J Hum Genet, 16(9):1075-1082.

[8]Hardman CA, Rogers PJ, Timpson NJ, et al., 2014. Lack of association between DRD2 and OPRM1 genotypes and adiposity. Int J Obes, 38(5):730-736.

[9]Imed H, Jihene MM, Hamida BH, et al., 2009. Tracking of overweight among urban school children: a 4 years cohort study in Sousse Tunisia. J Public Health Epidemiol, 1(1):31-36.

[10]Julia M, van Weissenbruch MM, Prawirohartono EP, et al., 2008. Tracking for underweight, overweight and obesity from childhood to adolescence: a 5-year follow-up study in urban Indonesian children. Horm Res, 69(5):301-306.

[11]Kvaløy K, Holmen J, Hveem K, et al., 2015. Genetic effects on longitudinal changes from healthy to adverse weight and metabolic status—the HUNT study. PLoS ONE, 10(10):e0139632.

[12]Nakano T, Sei M, Ewis AA, et al., 2010. Tracking overweight and obesity in Japanese children; a six years longitudinal study. J Med Invest, 57(1-2):114-123.

[13]Ng M, Fleming T, Robinson M, et al., 2014. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9945):766-781.

[14]Obregón AM, Valladares M, Goldfield G, 2017. Association of the dopamine D2 receptor rs1800497 polymorphism and eating behavior in Chilean children. Nutrition, 35: 139-145.

[15]Roth CL, Hinney A, Schur EA, et al., 2013. Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention. BMC Pediatr, 13:197.

[16]Sagar R, Gupta T, 2017. Psychological aspects of obesity in children and adolescents. Indian J Pediatr, 85(7):554-559.

[17]Skinner AC, Perrin EM, Moss LA, et al., 2015. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med, 373(14):1307-1317.

[18]Su LN, Wang YB, Wnag CG, et al., 2017. Network analysis identifies common genes associated with obesity in six obesity-related diseases. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 18(8):727-732.

[19]Trivedi S, Burton A, Oden J, 2014. Management of pediatric obesity: a lifestyle modification approach. Indian J Pediatr, 81(2):152-157.

[20]US Preventive Services Task Force, Grossman DC, Bibbins-Domingo K, et al., 2017. Screening for obesity in children and adolescents: US preventive services task force recommendation statement. JAMA, 317(23):2417-2426.

[21]van de Giessen E, Celik F, Schweitzer DH, et al., 2014. Dopamine D_2/3 receptor availability and amphetamine-induced dopamine release in obesity. J Psychopharmacol, 28(9):866-873.

[22]Vizcaíno FM, Aguilar FS, Artalejo FR, et al., 2002. Obesity prevalence and tracking of body mass index after a 6 years follow up study in children and adolescents: the Cuenca Study, Spain. Med Clín, 119(9):327-330.

[23]Wang SS, Lay S, Yu HN, et al., 2016. Dietary Guidelines for Chinese Residents (2016):comments and comparisons. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 17(9):649-656.

[24]Ward ZJ, Long MW, Resch SC, et al., 2017. Simulation of growth trajectories of childhood obesity into adulthood. N Engl J Med, 377(22):2145-2153.

[25]Yeh J, Trang A, Henning SM, et al., 2016. Food cravings, food addiction, and a dopamine-resistant (DRD2 A1) receptor polymorphism in Asian American college students. Asia Pac J Clin Nutr, 25(2):424-429.