CLC number: S852.4+2
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-09-10
Cited: 0
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Yan-Yi Che, Xiao-Jing Xia, Bo-Ping He, Yuan-Yuan Gao, Wen-Bo Ren, Hong-Tao Liu, Jian-Fang Liu, Ting-Hao Huang, Wen-Yu Han, Lian-Cheng Lei. A corn straw-based diet increases release of inflammatory cytokines in peripheral blood mononuclear cells of dairy cows[J]. Journal of Zhejiang University Science B, 2018, 19(10): 796-806.
@article{title="A corn straw-based diet increases release of inflammatory cytokines in peripheral blood mononuclear cells of dairy cows",
author="Yan-Yi Che, Xiao-Jing Xia, Bo-Ping He, Yuan-Yuan Gao, Wen-Bo Ren, Hong-Tao Liu, Jian-Fang Liu, Ting-Hao Huang, Wen-Yu Han, Lian-Cheng Lei",
journal="Journal of Zhejiang University Science B",
volume="19",
number="10",
pages="796-806",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700571"
}
%0 Journal Article
%T A corn straw-based diet increases release of inflammatory cytokines in peripheral blood mononuclear cells of dairy cows
%A Yan-Yi Che
%A Xiao-Jing Xia
%A Bo-Ping He
%A Yuan-Yuan Gao
%A Wen-Bo Ren
%A Hong-Tao Liu
%A Jian-Fang Liu
%A Ting-Hao Huang
%A Wen-Yu Han
%A Lian-Cheng Lei
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 10
%P 796-806
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700571
TY - JOUR
T1 - A corn straw-based diet increases release of inflammatory cytokines in peripheral blood mononuclear cells of dairy cows
A1 - Yan-Yi Che
A1 - Xiao-Jing Xia
A1 - Bo-Ping He
A1 - Yuan-Yuan Gao
A1 - Wen-Bo Ren
A1 - Hong-Tao Liu
A1 - Jian-Fang Liu
A1 - Ting-Hao Huang
A1 - Wen-Yu Han
A1 - Lian-Cheng Lei
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 10
SP - 796
EP - 806
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700571
Abstract: Recent studies have shown that diet can affect the body’s immunity. roughage of dairy cows consists of a variety of plant materials which make different contributions to health. This study investigated the effect of different roughages on the immunity of dairy cows. Serum, peripheral blood mononuclear cells (PBMCs), and milk samples were collected from 20 multiparous mid-lactation cows fed mixed forage (MF)- or corn straw (CS)-based diets. expression profile analysis was used to detect the differentially expressed genes (DEGs) from PBMCs. The results showed that milk protein in the MF group increased to 3.22 g/100 ml, while that of the CS group milk was 2.96 g/100 ml; by RNA sequencing, it was found that 1615 genes were differentially expressed between the CS group and the MF group among the 24 027 analyzed probes. Gene ontology (GO) and pathway analysis of DEGs suggested that these genes (especially genes coding cytokines, chemokine and its receptors) are involved in the immune response. Results were confirmed at the protein level via detecting the levels of interleukin-2 (IL-2), IL-6, IL-10, IL-12, leptin (LEP), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in peripheral blood by enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay analysis. Our data supported the conclusions that the protein content in milk of the MF group was higher than that of the CS group, the CS-based diets induced more release of cytokines than the MF-based diets in dairy cows’ PBMCs, and milk protein content may be affected by cytokines.
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