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Abstract: molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Short- or long-term exposure to these harmful substances often results in lung injury, causing respiratory and lung diseases. Acute and chronic respiratory diseases have high rates of morbidity and mortality and have become a major public health concern worldwide. For example, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. An increasing number of studies have revealed that hydrogen may protect the lungs from diverse diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. In this review, we highlight the multiple functions of hydrogen and the mechanisms underlying its protective effects in various lung diseases, with a focus on its roles in disease pathogenesis and clinical significance.

分子氢--一种具有广泛应用前景的肺部疾病治疗剂

概要：氢有多种生物学功能，在各种肺部疾病中有重要的保护作用，在临床中有广泛的应用前景。本综述基于截至2021年5月的出版物，通过PubMed数据库中的选择性搜索检索，包括临床试验、动物研究和综述，搜索词包括"氢""急性肺损伤""慢性阻塞性肺疾病""哮喘""癌症""肺病"，探讨了分子氢的作用机制及其对生物功能和细胞过程的影响，概述其对各种肺部疾病的研究现状，为基于分子氢的未来治疗方法的发展提供了理论支持。

关键词：分子氢；肺部疾病；活性氧（ROS）；氧化应激；炎症

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