Similar articles

Abstract: “Let food be thy medicine and medicine be thy food”—the ancient adage proposed by Greek philosopher Hippocrates of Kos thousands of years ago already acknowledged the importance of the beneficial and health-promoting effects of food nutrients on the body (Mafra et al., 2021). Recent epidemiological and large-scale community studies have also reported that unhealthy diets or eating habits may contribute heavily to the burden of chronic, non-communicable diseases, such as obesity, type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease (CVD), cancer, neurodegenerative diseases, arthritis, chronic kidney disease (CKD), and chronic obstructive pulmonary disease (COPD) (Jayedi et al., 2020; Gao et al., 2022). Emerging evidence highlights that a diet rich in fruits and vegetables can prevent various chronic diseases (Chen et al., 2022). food bioactive compounds including vitamins, phytochemicals, and dietary fibers are responsible for these nutraceutical benefits (Boeing et al., 2012). Recently, phytochemicals such as polyphenols, phytosterols, and carotenoids have gained increasing attention due to their potential health benefits to alleviate chronic diseases (van Breda and de Kok, 2018). Understanding the role of phytochemicals in health promotion and preventing chronic diseases can inform dietary recommendations and the development of functional foods. Therefore, it is crucial to investigate the health benefits of phytochemicals derived from commonly consumed foods for the prevention and management of chronic diseases.

专辑：分子营养与慢性疾病

[1]BaoT, KarimN, KeHH, et al., 2023. Polysaccharide isolated from wax apple suppresses ethyl carbamate-induced oxidative damage in human hepatocytes. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):574-586.

[2]BoeingH, BechtholdA, BubA, et al., 2012. Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr, 51(6):637-663.

[3]ChenW, XuY, ZhangLX, et al., 2016. Blackberry subjected to in vitro gastrointestinal digestion affords protection against Ethyl Carbamate-induced cytotoxicity. Food Chem, 212:620-627.

[4]ChenX, LiHY, ZhangB, et al., 2022. The synergistic and antagonistic antioxidant interactions of dietary phytochemical combinations. Crit Rev Food Sci Nutr, 62(20):5658-5677.

[5]FormanHJ, ZhangHQ, 2021. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov, 20(9):689-709.

[6]GaoL, GouN, YaoMJ, et al., 2022. Food-derived natural compounds in the management of chronic diseases via Wnt signaling pathway. Crit Rev Food Sci Nutr, 62(17):4769-4799.

[7]GowdV, SuHM, KarlovskyP, et al., 2018. Ethyl carbamate: an emerging food and environmental toxicant. Food Chem, 248:312-321.

[8]JayediA, SoltaniS, AbdolshahiA, et al., 2020. Healthy and unhealthy dietary patterns and the risk of chronic disease: an umbrella review of meta-analyses of prospective cohort studies. Br J Nutr, 124(11):1133-1144.

[9]LiYT, YeX, ZhengXD, et al., 2019. Transcription factor EB (TFEB)‍-mediated autophagy protects against ethyl carbamate-induced cytotoxicity. J Hazard Mater, 364:281-292.

[10]MaGX, DuHJ, HuQH, et al., 2022. Health benefits of edible mushroom polysaccharides and associated gut microbiota regulation. Crit Rev Food Sci Nutr, 62(24):6646-6663.

[11]MafraD, BorgesNA, LindholmB, et al., 2021. Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nat Rev Nephrol, 17(3):153-171.

[12]NorheimF, GjelstadI, HjorthM, et al., 2012. Molecular nutrition research: the modern way of performing nutritional science. Nutrients, 4(12):1898-1944.

[13]RahmanMA, SultanaA, KhanMF, et al., 2023. Tea tree oil, a vibrant source of neuroprotection via neuroinflammation inhibition: a critical insight into repurposing Melaleuca alternifolia by unfolding its characteristics. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):554-573.

[14]ShenLH, YangY, ZhangJL, et al., 2023. Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):587-601.

[15]SuHM, LiYT, HuDW, et al., 2018. Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state. Free Radical Biol Med, 126:269-286.

[16]SuHM, MoJL, NiJD, et al., 2020a. Andrographolide exerts antihyperglycemic effect through strengthening intestinal barrier function and increasing microbial composition of Akkermansia muciniphila. Oxid Med Cell Longev, 2020:6538930.

[17]SuHM, XieLH, XuY, et al., 2020b. Pelargonidin-3-O-glucoside derived from wild raspberry exerts antihyperglycemic effect by inducing autophagy and modulating gut microbiota. J Agric Food Chem, 68(46):13025-13037.

[18]SunY, ZhangZP, ChengL, et al., 2021. Polysaccharides confer benefits in immune regulation and multiple sclerosis by interacting with gut microbiota. Food Res Int, 149:110675.

[19]van BredaSGJ, deKok TMCM, 2018. Smart combinations of bioactive compounds in fruits and vegetables may guide new strategies for personalized prevention of chronic diseases. Mol Nutr Food Res, 62(1):1700597.

[20]WangJ, ZhaoXY, ZhengJW, et al., 2023. In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):602-616.

[21]XieLH, SuHM, SunCD, et al., 2018. Recent advances in understanding the anti-obesity activity of anthocyanins and their biosynthesis in microorganisms. Trends Food Sci Technol, 72:13-24.

[22]XieLH, MoJL, NiJD, et al., 2020. Structure-based design of human pancreatic amylase inhibitors from the natural anthocyanin database for type 2 diabetes. Food Funct, 11(4):2910-2923.

[23]XuY, XieLH, XieJH, et al., 2019. Pelargonidin-3-O-rutinoside as a novel α‍-glucosidase inhibitor for improving postprandial hyperglycemia. Chem Commun, 55(1):39-42.

[24]XuY, KeHH, LiYT, et al., 2021. Malvidin-3-O-glucoside from blueberry ameliorates nonalcoholic fatty liver disease by regulating transcription factor EB-mediated lysosomal function and activating the Nrf2/ARE signaling pathway. J Agric Food Chem, 69(16):4663-4673.

[25]XuY, LiYT, LiJX, et al., 2022. Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation. Redox Biol, 53:102349.

[26]YuPC, CaoJR, SunHX, et al., 2023. Andrographolide protects against atrial fibrillation by alleviating oxidative stress injury and promoting impaired mitochondrial bioenergetics. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):632-649.

[27]ZempleniJ, DanielH, 2003. Molecular Nutrition. CABI Publishing, Wallingford, New England, USA.

[28]ZhangX, DongZC, FanH, et al., 2023. Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-‍κB pathways. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):617-631.

[29]ZhaoWX, DuanCC, LiuYL, et al., 2023. Modulating effects of Astragalus polysaccharides on immune disorders via gut microbiota and the TLR4/NF-‍κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(7):650-662.