Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis
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Haoyi JIANG1, Longshan HAN1, Yifan HU1, Zhenhong YAN1, Qingbiao XU1, Xianghua YAN1,2. Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis",
author="Haoyi JIANG1, Longshan HAN1, Yifan HU1, Zhenhong YAN1, Qingbiao XU1, Xianghua YAN1,2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500583"
}
%0 Journal Article
%T Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis
%A Haoyi JIANG1
%A Longshan HAN1
%A Yifan HU1
%A Zhenhong YAN1
%A Qingbiao XU1
%A Xianghua YAN1
%A 2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500583
TY - JOUR
T1 - Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis
A1 - Haoyi JIANG1
A1 - Longshan HAN1
A1 - Yifan HU1
A1 - Zhenhong YAN1
A1 - Qingbiao XU1
A1 - Xianghua YAN1
A1 - 2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP - 0
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500583
Abstract: Endometritis, a prevalent disease of the reproductive tract, significantly reduces sows' reproductive performance and thus leads to substantial economic losses. limosilactobacillus vaginalis (LV) has been reported on its regulatory role in host immune capacity, while its mechanism of preventing endometritis remains unclear. Currently, no definitive diagnosis and effective treatment exists for this condition and antibiotics remain the most commonly used therapy. Herein, we investigated the potential of oral LV treatment as an effective antibiotic alternative for preventing endometritis in late-gestation sows. The results showed that orally administered LV significantly alleviated endometritis symptoms and moderately improved offspring growth performance. 16S rRNA sequencing revealed the significantly regulatory effects of LV on both gut and vaginal microbiota. Correspondingly, metabolic profiling indicated a shift towards better endometritis resistant landscape. Overall, the findings validate the roles of gut and vaginal microbiota as well as the utility of metabolic profiling in discovering the preventive effects of oral LV administration, establishing a link between intestinal probiotic supplementation and uterine health. Taken together, this study provides a novel antibiotic-free strategy for the treatment and prevention of sow endometritis.
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