Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses
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Huihua ZHEGN, Zheyi LIU, Xingyu DONG, Jinjia YANG, Junlong BI, Xiaodu WANG, Guanghong XIE, Dongbo SUN, Houhui SONG, Mingjun SU. Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses",
author="Huihua ZHEGN, Zheyi LIU, Xingyu DONG, Jinjia YANG, Junlong BI, Xiaodu WANG, Guanghong XIE, Dongbo SUN, Houhui SONG, Mingjun SU",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2600197"
}
%0 Journal Article
%T Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses
%A Huihua ZHEGN
%A Zheyi LIU
%A Xingyu DONG
%A Jinjia YANG
%A Junlong BI
%A Xiaodu WANG
%A Guanghong XIE
%A Dongbo SUN
%A Houhui SONG
%A Mingjun SU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2600197
TY - JOUR
T1 - Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses
A1 - Huihua ZHEGN
A1 - Zheyi LIU
A1 - Xingyu DONG
A1 - Jinjia YANG
A1 - Junlong BI
A1 - Xiaodu WANG
A1 - Guanghong XIE
A1 - Dongbo SUN
A1 - Houhui SONG
A1 - Mingjun SU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP - 0
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2600197
Abstract: swine enteric coronaviruses (SECoVs) are major pathogens that cause acute, lethal diarrhea in neonatal piglets. To invade intestinal epithelial cells, SECoVs must first breach the intestinal barrier. intestinal barrier function is relatively fragile in neonatal piglets due to their immature intestinal microecology and underdeveloped mucosal immunity. Furthermore, SECoVs can disrupt this barrier through multiple mechanisms, thereby accelerating infection. Consequently, maintaining intestinal barrier homeostasis represents a crucial strategic direction for the prevention and control of SECoVs infection. Intestinal probiotics and their metabolites play a critical role in maintaining intestinal barrier function, exerting protective effects by modulating the intestinal microecology, fortifying the mucus layer, enhancing tight junctions, and maintaining immune homeostasis. Bacteroides uniformis (b. uniformis), an important intestinal commensal bacterium, has demonstrated potential probiotic effects, including improvements in intestinal microecology and enhanced barrier function across various models of intestinal inflammation and metabolic disorder. However, direct evidence of its efficacy against SECoVs remains limited. This review therefore summarizes the mechanisms by which SECoVs disrupt the host intestinal barrier from microbial, chemical, physical, and immunological perspectives, and systematically outlines the potential roles of b. uniformis in barrier maintenance. The review thus provides a theoretical basis and identifies future research directions for the application of b. uniformis as a candidate probiotic for SECoVs prevention and control.
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