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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.8 P.665-674


Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea


Affiliation(s):  The Foundation for Medical Research, R.G. Thadani Marg, Worli, Mumbai 400018, India; more

Corresponding email(s):   fmrbom@hathway.com, ngcpr@lawkimindia.com, rojatkar@dalton.ncl.res.in, frchpune@giaspn01.vsnl.net.in

Key Words:  Pongamia pinnata, Medicinal plants, Diarrhea, Antidiarrheal agent, Enterotoxin, Colonization

BRIJESH S., DASWANI P.G., TETALI P., ROJATKAR S.R., ANTIA N.H., BIRDI T.J.. Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea[J]. Journal of Zhejiang University Science B, 2006, 7(8): 665-674.

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T1 - Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2006.B0665

While data are available on the effect of medicinal plants on intestinal motility and their antibacterial action, there is a paucity of information on their mode of action on various aspects of diarrheal pathogenicity, namely colonization to intestinal epithelial cells and production/action of enterotoxins. Crude decoction of dried leaves of Pongamia pinnata was evaluated for its antimicrobial (antibacterial, antigiardial and antirotaviral) effect; and its effect on production and action of enterotoxins (cholera toxin, CT; Escherichia coli labile toxin, LT; and E. coli stable toxin, ST); and adherence of enteropathogenic E. coli and invasion of enteroinvasive E. coli and Shigella flexneri to epithelial cells. The decoction had no antibacterial, antigiardial and antirotaviral activity, but reduced production of CT and bacterial invasion to epithelial cells. The observed results indicated that the crude decoction of P. pinnata has selective antidiarrheal action with efficacy against cholera and enteroinvasive bacterial strains causing bloody diarrheal episodes.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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