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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.4 P.484-488

http://doi.org/10.1631/jzus.2002.0484


Study of serum Helicobacter pylori soluble antigen


Author(s):  WU Qin-dong, ZHU Yong-liang

Affiliation(s):  Department of Gastroenterology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   wuqingdon@hzcnc.com

Key Words:  Helicobacter pylori, Antigen, Serology


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WU Qin-dong, ZHU Yong-liang. Study of serum Helicobacter pylori soluble antigen[J]. Journal of Zhejiang University Science A, 2002, 3(4): 484-488.

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author="WU Qin-dong, ZHU Yong-liang",
journal="Journal of Zhejiang University Science A",
volume="3",
number="4",
pages="484-488",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0484"
}

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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0484

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T1 - Study of serum Helicobacter pylori soluble antigen
A1 - WU Qin-dong
A1 - ZHU Yong-liang
J0 - Journal of Zhejiang University Science A
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SP - 484
EP - 488
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2002.0484


Abstract: 
Objective: to explore a new serological method for detecting Helicobac pylori (H. pylori) infection. Methods: Serum soluble antigen of H. pylori was detected by using avidin-biotin ELISA technique to evaluate the status of H. pylori infection and for comparison with rapid urease test (RUT), histologic examination and serology. Results: The sensitivity, specificity, positive predictive value and negative predictive value were 77.46%, 91.07%, 91.67% and 76.12%, respectively. The prevalence rate of serum H. pylori soluble antigen in 138 patients undergoing endoscopy was similar to the rate obtained by 14C-UBT methods (P>0.05). Conclusions: The detection of serum H. pylori soluble antigen (HpSAg) could be used as a new serological method which is accurate, and convenient, not affected by the memorizing reaction of serum antibody; is more sensitive, more specific and suitable for clinical diagnosis, and evaluation of eradication and for follow-up of H. pylori as well as for detection in children and pregnant women.

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Reference

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