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Journal of Zhejiang University SCIENCE A 2003 Vol.4 No.3 P.369-373

http://doi.org/10.1631/jzus.2003.0369


Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography


Author(s):  XU Geng, JIN Guo-dong, FU Guo-sheng, MA Ji, SHAN Jiang, WANG Jia-nan

Affiliation(s):  The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   xugengzju@21cn.com

Key Words:  Coagulation factor, Polymorphism, Coronary angiography, Myocardial infarction


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XU Geng, JIN Guo-dong, FU Guo-sheng, MA Ji, SHAN Jiang, WANG Jia-nan. Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography[J]. Journal of Zhejiang University Science A, 2003, 4(3): 369-373.

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author="XU Geng, JIN Guo-dong, FU Guo-sheng, MA Ji, SHAN Jiang, WANG Jia-nan",
journal="Journal of Zhejiang University Science A",
volume="4",
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pages="369-373",
year="2003",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2003.0369"
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%0 Journal Article
%T Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography
%A XU Geng
%A JIN Guo-dong
%A FU Guo-sheng
%A MA Ji
%A SHAN Jiang
%A WANG Jia-nan
%J Journal of Zhejiang University SCIENCE A
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%P 369-373
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%D 2003
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2003.0369

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T1 - Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography
A1 - XU Geng
A1 - JIN Guo-dong
A1 - FU Guo-sheng
A1 - MA Ji
A1 - SHAN Jiang
A1 - WANG Jia-nan
J0 - Journal of Zhejiang University Science A
VL - 4
IS - 3
SP - 369
EP - 373
%@ 1869-1951
Y1 - 2003
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2003.0369


Abstract: 
Objective: To determine whether polymorphisms in the genes for coagulation factor II,V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese. Methods: We screened coagulation factor II(G20210A), V(G1691A), VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay. Results: The R353Q and HVR4 genotype of the factor VII distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotype or allele did not show statistically significant differences between CAD group and controls or between male and female. The frequencies of the Q allele and (RQ+QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history than among those with MI history (P<0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factorII(G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls. Conclusion: The factor II(G20210A),V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese.

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Reference

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munsoor@university of sudan<mun.2000@yahoo.com>

2010-08-17 17:31:13

wanted this article to get the genotyping procedure thanks

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