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CLC number: R392

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Received: 2004-08-09

Revision Accepted: 2004-11-19

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.9 P.919-925

http://doi.org/10.1631/jzus.2005.B0919


In vitro study of immunosuppressive effect of apoptotic cells


Author(s):  ZHANG Wen-jin, ZHENG Shu-sen

Affiliation(s):  Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   zhengss@mail.hz.zj.cn

Key Words:  Macrophages, Apoptosis, Cytokines, Immunosuppression


ZHANG Wen-jin, ZHENG Shu-sen. In vitro study of immunosuppressive effect of apoptotic cells[J]. Journal of Zhejiang University Science B, 2005, 6(9): 919-925.

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author="ZHANG Wen-jin, ZHENG Shu-sen",
journal="Journal of Zhejiang University Science B",
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%T In vitro study of immunosuppressive effect of apoptotic cells
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%DOI 10.1631/jzus.2005.B0919

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T1 - In vitro study of immunosuppressive effect of apoptotic cells
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A1 - ZHENG Shu-sen
J0 - Journal of Zhejiang University Science B
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SP - 919
EP - 925
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2005.B0919


Abstract: 
Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages, in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα), interleukin-1beta (IL-1β) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Byrne, A., Reen, D.J., 2002. Lipopolysaccharide induces rapid production of IL-10 by monocytes in the presence of apoptotic neutropgils. J. Immunol., 168(4):1968-1997.

[2] Casciola-Roen, L.A., Anhalt, G., Rosen, A., 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med., 179(10):1317-1330.

[3] Chen, W.J., Frank, M.E., Jin, W.W., Wahl, S.M., 2001. TGF-(1 relased by apoptotic cells contributes to an immunosuppressive milieu. Immunity, 14(6):715-725.

[4] Crabtree, G.R., 1989. Contingent genetic regulatory events in T lymphocyte activation. Science, 243(4889):355-361.

[5] Crispe, I.N., Dao, T., Klugewitz, K., Wjatahat, Z.M., Danjela, P.M., 2000. The liver as a site of T-cell apoptosis: Graveyard, or killing field? Immunol. Rev., 174(2):47-62.

[6] Fadok, V.A., Bratton, D.L., Freed, P.W., Westcott, J.Y., Henson, P.M., 1998. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-(1, PGE2, and PAF. J. Clin. Invest., 101(4):890-898.

[7] Fadok, V.A., Bratton, D.L., Rose, D.M., Pearson, A., Ezekewitz, R.A., Henson, P.M., 2000. A receptor for phosphatidyiserine-specific clearance of apoptotic cells. Nature, 405(4):85-90.

[8] Freitas Balanco, J.M., Moreira, M.E., Bonomo, A., Bozza, P.T., Amarante-Mende, G., Pirmez, C., Barcinski, M.A., 2001. Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity. Current Biology, 11(23):1870-1873.

[9] Frerie-de-Lima, C.G., Nascunebto, D.O., Soares, M.B.P., Bozza, P.T., Casro-Faria-Neto, H.C., de Mello, F.G., DosReis, G.A., Lopes, M.F., 2000. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophage. Nature, 403(1):199-203.

[10] Matzinger, P., 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol., 12:991-1045.

[11] Mevorach, D., Zhou, J.L., Song, X., Elkon, K.B., 1998. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J. Exp. Med., 188(2):387-392.

[12] Reiter, I., Krammer, B., 1999. Cutting edge: Difference effect of apoptotic versus necrotic tumor cells on macrophage antitumer activity. J. Immunol., 163(6):1730-1732.

[13] Rovere, P., Sabbadini, M.G., Vallinoto, C., Fascio, U., Recihno, M., Ricciardi-Castagnoli, P., Rugarli, C., Manfredi, A.A., 1999. Dendritic cell prescentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti-beta2-gly-coprotein1antibodies. Arthritis Rheum, 42(7):1412-1420.

[14] Savill, J., 1998. Apoptosis: Phagocytic docking without shocking. Nature, 392(4):442-443.

[15] Savill, J., Dransfield, I., Gregory, C., Haslett, C., 2002. A blast from the past: Clearance of apoptotic cells regulates immune responses. Nature Reviews Immunology, 2(12):965-975.

[16] Voll, R.E., Herrmann, M., Roth, E.A., Stach, C., Kalden, J.R., 1997. Immunosuppressive effect of apoptotic cells. Nature, 390(11):350-351.

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