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Received: 2004-08-09

Revision Accepted: 2004-11-19

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.9 P.919-925


In vitro study of immunosuppressive effect of apoptotic cells

Author(s):  ZHANG Wen-jin, ZHENG Shu-sen

Affiliation(s):  Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   zhengss@mail.hz.zj.cn

Key Words:  Macrophages, Apoptosis, Cytokines, Immunosuppression

ZHANG Wen-jin, ZHENG Shu-sen. In vitro study of immunosuppressive effect of apoptotic cells[J]. Journal of Zhejiang University Science B, 2005, 6(9): 919-925.

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author="ZHANG Wen-jin, ZHENG Shu-sen",
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publisher="Zhejiang University Press & Springer",

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%DOI 10.1631/jzus.2005.B0919

T1 - In vitro study of immunosuppressive effect of apoptotic cells
A1 - ZHANG Wen-jin
A1 - ZHENG Shu-sen
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 9
SP - 919
EP - 925
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Y1 - 2005
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2005.B0919

Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages, in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα), interleukin-1beta (IL-1β) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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