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Abstract: Objective: To study the effect of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats. Methods: Full-thick myometrial strips were prepared from 18- to 21-day pregnant (n=8) and non-pregnant rats (n=7). After contractions became regular, strips were exposed to cumulative concentrations of the two drugs from 10⁻⁸ to 10⁻⁴ mol/L, amplitude and frequency of the uterine contraction was recorded. Results: Two local anesthetics caused a concentration dependent inhibition on contractility of myometrial strips from pregnant and non-pregnant rats. In the myometrium from non-pregnant rats, −logIC₅₀ of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine were 4.85 and 4.25 respectively. In the myometrium from pregnant rats, similar concentrations of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine were observed, −logIC₅₀ were 2.7 and 2.9 respectively. bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency. Conclusion: These results demonstrate that bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine may inhibit myometrium contractility. The inhibitory effect of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine or bupivacaine is not enhanced by gestation in rat. bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium.

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