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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.12 P.987-991

http://doi.org/10.1631/jzus.2006.B0987


A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial


Author(s):  FAN Yu-jing, CHEN Shu-jie, YU Ying-cong, SI Jian-min, LIU Bin

Affiliation(s):  Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   sijm@163.net

Key Words:  Irritable bowel syndrome (IBS), Intestinal flora, Probiotic agents


FAN Yu-jing, CHEN Shu-jie, YU Ying-cong, SI Jian-min, LIU Bin. A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial[J]. Journal of Zhejiang University Science B, 2006, 7(12): 987-991.

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author="FAN Yu-jing, CHEN Shu-jie, YU Ying-cong, SI Jian-min, LIU Bin",
journal="Journal of Zhejiang University Science B",
volume="7",
number="12",
pages="987-991",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0987"
}

%0 Journal Article
%T A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial
%A FAN Yu-jing
%A CHEN Shu-jie
%A YU Ying-cong
%A SI Jian-min
%A LIU Bin
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 12
%P 987-991
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0987

TY - JOUR
T1 - A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial
A1 - FAN Yu-jing
A1 - CHEN Shu-jie
A1 - YU Ying-cong
A1 - SI Jian-min
A1 - LIU Bin
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 12
SP - 987
EP - 991
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0987


Abstract: 
Objective: To evaluate the efficacy and safety of live combined Bifidobacterium, Lactobacillus and Enterococcus capsules in treatment of irritable bowel syndrome. Methods: Eighty-five patients [male 32, female 53; age (45.31±11.72) years] were given live combined Bifidobacterium, Lactobacillus and Enterococcus capsules 1260 mg/d t.i.d.×4 weeks. Syndrome scales were used to evaluate the efficacy in gastrointestinal syndrome. Fecal flora was also measured before and after the treatment. Six bacteria were cultured and the colony forming units were counted in stool. SPSS was used for data analysis. Results: Seventy-four patients finished the follow-up. No side-effect was found. For treatment of irritable bowel syndrome, the effective rate of live combined Bifidobacterium, Lactobacillus and Enterococcus capsules was 56.8% in the second week, 74.3% in the fourth week and 73.0% in the sixth week. Single symptom was improved, especially in abdominal pain and stool character. The probiotica containing live combined Bifidobacterium, Lactobacillus and Enterococcus could increase bifidobacterium count (P<0.01) and lactobacillus count (P<0.05); decrease bacteroides count (P<0.05) and enterococci count (P<0.01); No obvious changes were observed in clostridium difficile colonitis and enterobacteriaceae (P>0.05). Conclusion: The result of the study indicated that the administration of live combined Bifidobacterium, Lactobacillus and Enterococcus improved the symptom of irritable bowel syndrome and that there was a gradual increase of this effect. Thereafter conditions remained stable for 2 weeks. That improvement may be associated with alterations in gastrointestinal flora.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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